Results 51 to 60 of about 71,530 (316)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Preparation and improved mechanical properties of three-dimensional woven fabrics reinforced thermoplastic composites based on intra-yarn hybrid flax/basalt fibers

open access: yesIndustrial Crops and Products
Three-dimensional (3D) woven fabric reinforced thermoplastic composites with natural and synthetic hybrid fibers have advantages of high modulus, recyclability, excellent structure integrality and delamination resistance. However, the full penetration of
Ziyan Niu   +5 more
doaj   +1 more source

Mechanical and moisture diffusion behaviour of hybrid Kevlar/Cocos nucifera sheath reinforced epoxy composites

open access: yesJournal of Materials Research and Technology, 2019
The aim of this research is partial replacement of plain woven Kevlar 29(K) with naturally woven cocous nucifera sheath (CS) waste. Laminated K/CS reinforced epoxy hybrid composites were fabricated by hand lay-up method followed by hot compression ...
J. Naveen   +4 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

Hybrid magnesium matrix composites: A review of reinforcement philosophies, mechanical and tribological characteristics

open access: yesReviews on Advanced Materials Science, 2023
Magnesium hybrid composites are a new class of lightweight metal matrix composites having excellent physical, mechanical, wear and corrosive properties.
Khatkar Sandeep Kumar
doaj   +1 more source

HYPE: Hybrid modelling by composition of flows

open access: yesFormal Aspects of Computing, 2013
Abstract Hybrid systems are manifest in both the natural and the engineered world, and their complex nature, mixing discrete control and continuous evolution, make it difficult to predict their behaviour. In recent years several process algebras for modelling hybrid systems have appeared in the literature, aimed at addressing this problem ...
Vashti Galpin   +2 more
openaire   +3 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Mechanical performance of aramid/glass fiber hybrid weft-knitting-reinforced composites under low-velocity impact

open access: yesJournal of Industrial Textiles, 2023
In response to the defects of easy delamination, poor impact resistance, and low toughness in laminates, intra-layer aramid/glass hybrid weft-knitted reinforced composites without lamination were designed and prepared. This paper investigated the tensile,
Tingting Dong   +3 more
doaj   +1 more source

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