Results 181 to 190 of about 10,140 (258)

A Single‐Enzyme Activated CRISPR‐Cas12a Nano System via Subtly Balanced dsDNA for Kinetic‐Gated UDG Detection and Spatiotemporal Cellular Imaging

open access: yesAdvanced Science, EarlyView.
Kinetic‐gated CRISPR–Cas12a activation enables single‐enzyme detection and spatiotemporal imaging of UDG ABSTRACT Uracil‐DNA glycosylase (UDG) is a key enzyme in base excision repair and an important biomarker for genomic stability and disease. In many reported sensing systems, uracil excision is coupled to signal generation through additional ...
Kejun Dong   +12 more
wiley   +1 more source

Lithiation‐Driven LiCrSe2 Shell Growth on Metallic CrSe2 Core Governs the Plateau–Slope Behavior

open access: yesAdvanced Science, EarlyView.
Layered CrSe2 is investigated as a lithium‐ion battery cathode combining fast Li+ diffusion and structural reversibility. Calculations and experiments reveal a single topotactic intercalation process with a characteristic plateau–slope profile governed by lithiation‐induced conductivity changes. A core‐shell lithiation evolution underpins its high‐rate
Weihao Li   +15 more
wiley   +1 more source

G4‐Ligand‐Directed PROTACs Unveil DR1 as a Novel Ligand‐Co‐Binding G4‐Protein and Reshape G4‐Dependent Transcription

open access: yesAdvanced Science, EarlyView.
G4‐binding proteins (G4BPs) that specifically co‐bind G4s in the presence of small‐molecule ligands represent a critical but unexplored class of proteins. We introduce G4‐Ligand‐Directed PROTACs (G4L‐TACs), a chemical platform that couples G4 ligands (PDS) to E3 recruiters to selectively degrade these ligand‐co‐binding G4BPs.
Mao‐Lin Li   +8 more
wiley   +1 more source

Multifunctional Phosphate Monomer Enabling LiNO3 Solvation and In Situ Formation of Flame‐Retardant Gel Polymer Electrolyte for High‐Voltage Lithium Metal Batteries

open access: yesAdvanced Science, EarlyView.
A phosphorus‐containing multifunctional monomer is successfully synthesized to simultaneously enable the dissolution of lithium nitrate in ester‐based electrolytes and in situ form a flame‐retardant gel polymer electrolyte (GPE). The formed GPE effectively stabilizes the structures of both the cathode and anode, thereby achieving superior long‐term ...
Lijun Ma   +5 more
wiley   +1 more source

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