Results 221 to 230 of about 49,201 (297)

The Evolution and Integration of ESG Reporting: A Framework for Sustainable Business Accountability

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examines how multinational corporations incorporate Environmental, Social, and Governance (ESG) reporting frameworks to foster trust, enhance legitimacy, and move beyond mere symbolic disclosure. A qualitative comparison of Microsoft and Unilever from 2020 to 2023 assesses how both firms integrate leading standards, including GRI ...
Gabriela Marques Alves Aguiar
wiley   +1 more source

The role of HNF4α in adenocarcinoma. [PDF]

Biochem Soc Trans
Essel Dadzie H, Snyder EL.
europepmc   +1 more source

De Novo Design of Multivalent α/β‐Peptides Mimicking Transcription Factors Targeting the CBP KIX Domain

Chemistry – A European Journal, EarlyView.
A modular, de novo α/β‐peptide design strategy allows fine‐tuning of ligand properties, resulting in multivalent ligands that simultaneously target separate binding sites on the protein surface. ABSTRACT Protein‐protein interactions that regulate gene expression in the nucleus are increasingly recognized as potential therapeutic targets but present ...
Márk V. Tresztián, Vencel L. Petrovicz, Edit Wéber, Tamás A. Martinek, Zsófia Hegedüs   +4 more
wiley   +1 more source

Rank signaling drives basal cell-lineage infidelity leading to mammary tumorigenesis. [PDF]

Nat Commun
Redondo-Pedraza J, Santamaría PG, Sanchez-Juan A, Jimenez M, Rocha AS, Soria-Alcaide G, Terrón-Bautista J, Álvarez R, López V, Graña-Castro O, Caleiras E, Ximénez-Embún P, Bergholtz H, Dalal H, Gray GK, Isasa M, Sørlie T, Khaled WT, Cortés-Ledesma F, Mueller CG, González-Suárez E.   +20 more
europepmc   +1 more source

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Use of 5‐HT3 Receptor Antagonists: 2026 Update

Clinical Pharmacology &Therapeutics, EarlyView.
5‐hydroxytryptamine type 3 (5‐HT3) receptor antagonists are used to treat nausea and vomiting and in the prevention of chemotherapy‐induced, radiation‐induced, and postoperative nausea and vomiting. Most of the 5‐HT3 receptor antagonists (i.e., ondansetron, tropisetron, dolasetron, palonosetron, and ramosetron) are metabolized by CYP2D6, but the extent
Claire Moore, Melissa S. Bourque, Andreas Halman, José A. G. Agúndez, Cynthia A. Prows, Keiko Hikino, Matthias Schwab, Carolyn J. Oxencis, Dharmisha Chauhan, Meta H.M. Diekstra, Susie E. Long, Gillian C. Bell, Andrea Gaedigk, Michelle Whirl‐Carrillo, Teri E. Klein, Kelly E. Caudle, Rachel Conyers   +16 more
wiley   +1 more source

Data lineage tracking and visualization with Microsoft Purview

Datu līnijas izsekojamība datu pārvaldībā ir kļuvusi par aktuālu un būtisku aspektu, jo tā nodrošina datu caurredzamību un palielina pārvaldības procesu efektivitāti. Bakalaura darba pētījuma mērķis bija izpētīt Microsoft Purview pielietojumu datu līniju
Ļaksa, Ralfs
core  

Does Next Generation Sequencing (NGS)‐Based CYP2D6 Sequencing Improve Genotype–Phenotype Concordance in Tamoxifen‐Treated Patients?

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2D6 metabolizes about 20% of commonly used drugs, including tamoxifen, a major hormone therapy for breast cancer. Although the relationship between tamoxifen pharmacokinetics and CYP2D6 genotype has been demonstrated, residual variability in drug exposure remains unexplained.
Jeanne Petit, Julien Plenecassagnes, Aurelie Brice, Florence Dalenc, Ludovic Mallet, Etienne Chatelut, Ayman Al Saati, Fabienne Thomas   +7 more
wiley   +1 more source

Introgression and parental conflict shape repeated occurrences of postzygotic isolation in Mimulus. [PDF]

Curr Biol
Frayer ME, Soliman HK, Schwarz PF, Coughlan JM.   +3 more
europepmc   +1 more source

Benchmark of Open‐Access Star‐Allele Callers to Accurately Assess Haplotypes and Phenotypes in Pharmacogenetic Studies

Clinical Pharmacology &Therapeutics, EarlyView.
Genetic polymorphisms are common in pharmacogenes, with sometimes important implications for drug metabolism. Assessing the correct enzyme phenotype from genetic data is thus a crucial step into the development of personalized medicine. Many bioinformatics star‐allele callers have been developed for this purpose of identifying the correct star alleles ...
Marc B. Gros‐La‐Faige, Emmanuelle Génin, Anthony F. Herzig   +2 more
wiley   +1 more source

Beyond livestock: the genomic evolution and expansion of MRSA CC398 as a healthcare- and community-associated pathogen (2017-2024). [PDF]

Microb Genom
Tkadlec J, Rozsypalkova A, Polivkova S, Drevinek P, Gooskens J, Krutova M.   +5 more
europepmc   +1 more source