Results 31 to 40 of about 155,289 (268)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A Hybrid Framework for Offshore Wind Power Forecasting: Integrating CNN-BiGRU-XGBoost with Advanced Feature Engineering and Analysis

Energies
This paper proposes a hybrid forecasting model for offshore wind power, combining CNN, BiGRU, and XGBoost to address the challenges of fluctuating wind speeds and complex meteorological conditions.
Yongguo Li, Jiayi Pan, Jiangdong Wang
doaj   +1 more source

An EMD–SARIMA-Based Modeling Approach for Air Traffic Forecasting

Algorithms, 2017
The ever-increasing air traffic demand in China has brought huge pressure on the planning and management of, and investment in, air terminals as well as airline companies.
Wei Nai, Lu Liu, Shaoyin Wang, Decun Dong   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Hydraulic simulation method for refined oil pipelines based on error compensation and time-delay extraction

You-qi chuyun
ObjectiveThe flow and pressure in the refined oil pipeline undergo rapid changes during operating condition transitions. Accurate estimation of these changes is crucial for safe pipeline operation.
Haoyang SUN, Jian DU, Zixing FAN, Qi LIAO, Yu HE, Runbin XUE, Yongtu LIANG   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Hybrid Stochastic–Machine Learning Framework for Postprandial Glucose Prediction in Type 1 Diabetes

Algorithms
This research introduces a hybrid framework that integrates stochastic modeling and machine learning for predicting postprandial glucose levels in individuals with Type 1 Diabetes (T1D).
Irina Naskinova, Mikhail Kolev, Dilyana Karova, Mariyan Milev   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Predicting Extreme Environmental Values with Hybrid Models: A Perspective Across Air Quality, Wind Energy, and Sensor Networks

Sensors
This Perspective synthesizes recent (2023–2025) progress in predicting extreme environmental values by combining empirical formulations, physics-based simulation outputs, and sensor-network data.
George Efthimiou
doaj   +1 more source

The Semantics of Hybrid Process Models [PDF]

, 2016
In the area of business process modelling, declarative notations have been proposed as alternatives to notations that follow the dominant, imperative paradigm. Yet, the choice between an imperative or declarative style of modelling is not always easy to make. Instead, a mixture of these styles is sometimes preferable.
Slaats, Tijs, Schunselaar, Dennis M. M., Maggi, Fabrizio M., Reijers, Hajo A.   +3 more
openaire   +5 more sources