Results 71 to 80 of about 155,289 (268)
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
Integration of AI-driven digital twins for real-time optimization of renewable energy grids
Frontiers in Energy ResearchThe increasing integration of renewable energy sources, such as solar photovoltaics, wind turbines, hydropower, and energy storage systems, introduces substantial variability and complexity into modern power grids.
Chinyere Nneoma Ugwu +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
Hybrid Modeling for Bioprocesses: Architectures, Applications, and Perspectives
Engineering ReportsRecent hardware developments within industrial digitalization make more evident the need of high‐fidelity models to exploit process system engineering potential in biomanufacturing.
Juan Federico Herrera‐Ruiz +2 more
doaj +1 more source
Parallel Hybrid Modeling of Al–Mg–Si Tensile Properties Using Density-Based Weighting
MetalsA hybrid modeling framework for predicting the mechanical properties of Al-Mg-Si alloys, that blends physics-based and machine-learning models, is developed and tested.
Christian Dalheim Øien +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court +3 more
wiley +1 more source
ISPRS International Journal of Geo-InformationDespite concern over air pollution, fine-scale spatial and demographic disparities in exposure remain largely unquantified in Australian cities due to sparse monitoring and coarse models.
Jun Gao +12 more
doaj +1 more source
Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1
FEBS Open Bio, EarlyView.The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn +2 more
wiley +1 more source