Results 71 to 80 of about 187,858 (317)

A Hybrid Methodology Using Machine Learning Techniques and Feature Engineering Applied to Time Series for Medium- and Long-Term Energy Market Price Forecasting

Energies
In the electricity market, the issue of contract negotiation prices between generators/traders and buyers is of particular relevance, as an accurate contract modeling leads to increased financial returns and business sustainability for the various ...
Flávia Pessoa Monteiro, Suzane Monteiro, Carlos Rodrigues, Josivan Reis, Ubiratan Bezerra, Maria Emília Tostes, Frederico A. F. Almeida   +6 more
doaj   +1 more source

Enhancing Cryptocurrency Prediction: A Fusion of Machine Learning and Neutrosophic Programming [PDF]

Neutrosophic Sets and Systems
Fluctuations in cryptocurrency markets present a significant problem to the accuracy of forecasting trends and prices in this field. This paper proposes a new method of improving cryptocurrency forecasting by applying machine learning algorithms to a ...
Ahmad Yusuf Adhami, Mohammad Parvej, Nabil Ahmed Khan, Mohd Khalid   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Enhancing Supercapacitor Simulation Accuracy Through a Novel Hybrid Modeling Approach

Applied Sciences
In the last 2 decades, supercapacitors have become an important component in the hybrid energy-storage system, in combination with batteries. The resulting system offers higher performance in comparison to classic energy storage systems due to the ...
Diana Lemian, Florin Ioan Bode, Ciprian Lapusan   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Displaced geostationary orbits using hybrid low-thrust propulsion [PDF]

, 2012
In this paper, displaced geostationary orbits using hybrid low-thrust propulsion, a complementary combination of Solar Electric Propulsion (SEP) and solar sailing, are investigated to increase the capacity of the geostationary ring that is starting to ...
Biggs, James, Jeannette Heiligers, BIGGS, JAMES DOUGLAS, Heiligers, Jeannette, McInnes, Colin, Ceriotti, Matteo, Heiligers, J., Ceriotti, M., Mcinnes, Colin R., Biggs, J.D., Colin R. McInnes, James D. Biggs, Matteo Ceriotti, McInnes, C.R.   +13 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source