Results 61 to 70 of about 112,659 (314)
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Advances in Mechanical Engineering, 2020 The power-split hybrid electric vehicle (PS-HEV) has multiple working modes to maintain high operation efficiency according to different conditions. The main modes involved in the vehicle driving process are pure electric mode and the hybrid driving mode.
Dou Lei +6 more
doaj +1 more source
Mode recognition and coordinated magnetisation control method for variable flux memory machine
Electronics Letters, 2021 The hybrid permanent magnet (PM) variable flux memory machine employs high‐ and low‐coercive‐force hybrid PMs to simultaneously obtain a high torque density and regulable PM flux property. The operating trajectories and steady working‐points of this type
Wei Wang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Hybrid simulation and modes of governance in UK healthcare [PDF]
, 2011 PurposeHealthcare organisations exhibit detail and dynamic complexity. It has been argued that discrete event simulation (DES) is ideal for problems exhibiting detail complexity and system dynamics (SD) lends itself naturally to comprehend dynamic ...
Kirandeep Chahal, Tillal Eldabi
core +1 more source
AIP Advances, 2015 We experimentally demonstrated enhanced spontaneous and stimulated emission of GaAs/AlGaAs nanowire via the Purcell effect. By integrating the NW and SiO2-Au substrate, the hybridization of the dielectric modes in the NW with surface plasmons on the ...
Wei Wei, Xia Zhang, Xin Yan, Xiaomin Ren
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
[Design and Investigation of a Hybrid Optical Resonator for Medium Energy COIL] [PDF]
, 2007 High brightness laser radiation of chemical oxygen iodine lasers (COIL) requires resonator types especially adapted to low gain medium and rectangular cavity geometry.
Grünewald, Karin +3 more
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