Results 91 to 100 of about 16,162 (247)

Adaptive divergence in shoot gravitropism creates hybrid sterility in an Australian wildflower. [PDF]

Proc Natl Acad Sci U S A, 2021
Wilkinson MJ, Roda F, Walter GM, James ME, Nipper R, Walsh J, Allen SL, North HL, Beveridge CA, Ortiz-Barrientos D.   +9 more
europepmc   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Liquid Metal Microrobots for Magnetically Guided Transvascular Navigation

Advanced Materials, EarlyView.
Liquid metal‐based microrobots combine magnetic steering, intrinsic X‐ray visibility and softness, to navigate blood vessels even against flow. Under clinically relevant magnetic fields, liquid metal microrobots roll along vessel walls, cross endothelial barriers, and accumulate in target tissues.
Xiaohui Ju, Roshan Velluvakandy, Xianghua Wu, Miguel Angel Merlos Rodrigo, Zbyněk Heger, Kamila Bendíčková, Jan Frič, Martin Pumera   +7 more
wiley   +1 more source

Machine Learning‐Informed Nano Co‐Assembly Inhibits Fibroblast Activation Protein and Improves Drug Delivery in Fibrotic Tissue

Advanced Materials, EarlyView.
We present SP‐13786 (SP), a fibroblast activation protein (FAP) inhibitor, as a universal excipient for co‐assembling stable drug nanoparticles (SCAN). Assembly mechanism deciphered by molecular dynamics and explainable machine learning, SCAN attenuate fibrosis‐induced stromal barriers, enhances lesional drug accumulation, and improves therapeutic ...
Zehua Liu, Qiang Long, Yihao Liu, Xiuqiao Sun, Baoding Zhang, Binxin Liao, Weibin Wu, Wangxi Hai, Pei Zhang, Wenhua Lian, Yuewen Zhu, Zheng Wang, Caisheng Wu, Xianming Deng, Hélder A. Santos, Xiaofeng Ye   +15 more
wiley   +1 more source

Oxygen‐Inhibition Driven Compartmentalization of Dextran Microgels: Toward Fusible Colloidal Biomaterial Inks for 3D Printing

Advanced Materials, EarlyView.
Harnessing oxygen inhibition as a materials design principle enables the universal fabrication of core–shell microgels with tunable radial crosslinking gradients. This conceptually simple yet highly versatile strategy generates fusible colloidal bioinks that combine structural hierarchy with adaptive porosity.
Selin Bulut, Thomas Bissing, Tudor Lile, Hannah Küttner, Daniel Günther, Cédric Bergerbit, Dan Eugen Demco, Laura De Laporte, Andrij Pich   +8 more
wiley   +1 more source

Patterns of reproductive isolation in a haplodiploid mite, Amphitetranychus viennensis: prezygotic isolation, hybrid inviability and hybrid sterility. [PDF]

BMC Ecol Evol, 2021
Sato Y, Fujiwara S, Egas M, Matsuda T, Gotoh T.   +4 more
europepmc   +1 more source

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, EarlyView.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

Genetic Analysis of S5-Interacting Genes Regulating Hybrid Sterility in Rice. [PDF]

Rice (N Y), 2021
Rao J, Wang X, Cai Z, Fan Y, Yang J.
europepmc   +1 more source

Roadmap to Precision 3D Printing of Cellulose: Rheology‐Guided Formulation, Fidelity Assessment, and Application Horizons

Advanced Materials Technologies, EarlyView.
This critical review presents a comprehensive roadmap for the precision 3D printing of cellulose. Quantitative correlations link ink formulation and rheological properties to print fidelity and final material performance. This framework guides the development of advanced functional materials, from biomedical scaffolds to electromagnetic shielding ...
Majed Amini, Hadi Hosseini, Seyyed Alireza Hashemi, Mohammad Arjmand   +3 more
wiley   +1 more source

Advanced Mounting Technique for Improved Imaging and Analysis of Embedded Spheroids and Migrating Cells in Light Sheet Fluorescence Microscopy

Advanced Materials Technologies, EarlyView.
A novel sample holder compatible with the Zeiss Lightsheet 7 microscope improves imaging of spheroids embedded in collagen matrices. By enabling dual‐sided illumination, it enhances image quality and quantitative analysis of migrating cells. This method advances 3D light sheet microscopy for studying tumor invasion and therapeutic responses.
Masoumeh Mohamadian Namaqi, Franziska Moll, Robert Römer, Andreas Grodrian, Doris Heinrich, Karen Lemke   +5 more
wiley   +1 more source