Results 81 to 90 of about 45,642,631 (346)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
MarStra – An intelligent hybrid system for developing marketing strategies
, 1998 An intelligent hybrid software system for formulating marketing ...
Li, Shuliang
core
Advances in the Study of Techniques to Determine the Lithium-Ion Battery’s State of Charge
EnergiesThis study explores the challenges and advances in the estimation of the state of charge (SOC) of lithium-ion batteries (LIBs), which are crucial to optimizing their performance and lifespan. This review focuses on four main techniques of SOC estimation:
Xinyue Liu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
A stochastic hybrid control law for a localization task based on active sensing [PDF]
, 2023 openA localization task by a mobile agent is considered, where the sensing and the motion actions are performed exclusively with respect to each other, meaning that sensing the target is not available during the agent movement. To formalize this scenario
DE LAZZARI, GIACOMO
core
HeliyonProton-exchange membrane (PEM) dry–wet variation during PEM fuel cell (PEMFC) operation markedly affects PEMFC lifespan. Therefore, deeper insights into the mechanical degradation mechanism of PEM require analysis of the membrane dry–wet change process ...
Xin Zhan +5 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
, 1999 An intelligent hybrid system for developing global strategies and associated Internet ...
Li, Shuliang
core
Cross-linked chitosan/liposome hybrid system for the intestinal delivery of quercetin.
Journal of Colloid and Interface Science, 2016 Quercetin is a flavonoid with antioxidant/anti-inflammatory properties, poorly absorbed when administered orally. To increase its bioavailability and optimize its release in the intestine, a hybrid system made of liposomes coated with cross-linked ...
C. Caddeo +7 more
semanticscholar +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source