Results 41 to 50 of about 1,959,519 (287)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
How to Exploit the Glass Mass for Damping a Building?
Challenging Glass Conference Proceedings, 2022 The worlds spectacular skylines host tall and slender buildings to create a maximum of office, residential and commercial space on a minimized footprint.
Michael Engelmann +7 more
doaj
Frontiers in Plant Science, 2022 Following the “green revolution,” indica and japonica hybrid breeding has been recognized as a new breakthrough in further improving rice yields. However, heterosis-related grain weight QTLs and the basis of yield advantage among subspecies has not been ...
Weilong Kong +6 more
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
MetalsThe optimization of process parameters in powder Directed Energy Deposition (DED) is essential for achieving consistent, high-quality bead geometries, which directly influence the performance and structural integrity of fabricated components. As a subset
Deviprasad Chalicheemalapalli Jayasankar +5 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Life cycle engineering of lightweight structures in vehicles for on-demand mobility services
Cleaner Engineering and TechnologyTo reduce transport-related environmental impacts, innovative mobility system approaches such as on-demand services are being developed. These can include operating vehicles that differ regarding their characteristics and application profile from ...
Moritz Ostermann +3 more
doaj +1 more source
Hybrid Quantum-Classical Master Equations
, 2014 We discuss hybrid master equations of composite systems which are hybrids of classical and quantum subsystems. A fairly general form of hybrid master equations is suggested, its consistency is derived from the consistency of Lindblad quantum master ...
Diósi, Lajos
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source