Results 61 to 70 of about 416,460 (269)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Decoding Imagined 3D Hand Movement Trajectories From EEG: Evidence to Support the Use of Mu, Beta, and Low Gamma Oscillations

Frontiers in Neuroscience, 2018
Objective: To date, motion trajectory prediction (MTP) of a limb from non-invasive electroencephalography (EEG) has relied, primarily, on band-pass filtered samples of EEG potentials i.e., the potential time-series model.
Attila Korik, Ronen Sosnik, Nazmul Siddique, Damien Coyle   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Decoding Imagined 3D Arm Movement Trajectories From EEG to Control Two Virtual Arms—A Pilot Study

Frontiers in Neurorobotics, 2019
Background: Realization of online control of an artificial or virtual arm using information decoded from EEG normally occurs by classifying different activation states or voluntary modulation of the sensorimotor activity linked to different overt actions
Attila Korik, Ronen Sosnik, Nazmul Siddique, Damien Coyle   +3 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Dynamic programming in package Mathematica [PDF]

ITM Web of Conferences
Dynamic programming (DP) is a powerful algorithmic technique for solving optimization problems by breaking them down into simpler subproblems. This paper presents an implementation of DP algorithms for two classic optimization problems: the Knapsack ...
Stanimirović Predrag S., Stupin Artem
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Verification of Hybrid Systems [PDF]

, 2007
Embedded digital systems have become ubiquitous in everyday life. Many such systems, including many of the safety-critical ones, operate within or comprise tightly coupled networks of both discrete-state and continuous-state components. The behavior of such hybrid discrete-continuous systems cannot be fully understood without explicitly modeling and ...
openaire   +1 more source

The Influence of Ultrasonic Irradiation of a 316L Weld Pool Produced by DED on the Mechanical Properties of the Produced Component

Crystals
Additive manufacturing of metallic components often results in the formation of columnar grain structures aligned along the build direction. These elongated grains can introduce anisotropy, negatively impacting the mechanical properties of the components.
Dennis Lehnert, Christian Bödger, Philipp Pabel, Claus Scheidemann, Tobias Hemsel, Stefan Gnaase, David Kostka, Thomas Tröster   +7 more
doaj   +1 more source