Results 41 to 50 of about 412,677 (269)

De novo assembly of two chromosome-level rice genomes and bin-based QTL mapping reveal genetic diversity of grain weight trait in rice

Frontiers in Plant Science, 2022
Following the “green revolution,” indica and japonica hybrid breeding has been recognized as a new breakthrough in further improving rice yields. However, heterosis-related grain weight QTLs and the basis of yield advantage among subspecies has not been ...
Weilong Kong, Xiaoxiao Deng, Zhenyang Liao, Yibin Wang, Mingao Zhou, Zhaohai Wang, Yangsheng Li   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Life cycle engineering of lightweight structures in vehicles for on-demand mobility services

Cleaner Engineering and Technology
To reduce transport-related environmental impacts, innovative mobility system approaches such as on-demand services are being developed. These can include operating vehicles that differ regarding their characteristics and application profile from ...
Moritz Ostermann, Eric Dierkes, Thorsten Marten, Thomas Tröster   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Numerical Modeling and Analysis of Shadow Flicker Using Solar Path Functions for Enhanced Predictive Accuracy

Energies
Shadow flicker caused by wind turbine blades passing through sunlight can significantly affect nearby residential buildings, raising environmental and regulatory concerns in wind farm development.
Nicolai Radke, Patrick E. M. De Smet, Erika Ábrahám   +2 more
doaj   +1 more source

Global Asymptotic Convergent Observer for SLAM

IEEE Access, 2022
This paper investigates the global convergence problem of SLAM algorithms, a problem that has been subject to topological obstacles. This is due to the fact that state-space of attitude kinematics, $SO(3)$ , is a non-contractible manifold. Hence, $SO(3)
Seyed Hamed Hashemi, Jouni Mattila
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Artificial Neuron-Based Model for a Hybrid Real-Time System: Induction Motor Case Study

Mathematics, 2022
Automatic Machine Learning (AML) methods are currently considered of great interest for use in the development of cyber-physical systems. However, in practice, they present serious application problems with respect to fitness computation, overfitting ...
Manuel I. Capel
doaj   +1 more source