Results 111 to 120 of about 535,760 (311)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Evidence of genetic hybridization of the wild boar and the indigenous black pig in Northern Greece [PDF]

Biotechnology in Animal Husbandry, 2018
In Greece both the black indigenous pig and the wild boar are considered as species of valuable genetic diversity while their products achieve a valuable market price.
Laliotis George P., Avdi Meni
doaj  

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Construction of Genetic Linkage Maps Using SSR Markers and Identification of Flower Bud-Related QTLs in Nightlily (Hemerocallis citrina)

Agronomy
Nightlily (Hemerocallis citrina Baroni) is an important vegetable with edible floral organs. It possesses considerable economic value due to its edibility, ornamental, and medicinal properties.
Feifan Hou, Xufei Liang, Rui Chen, Xuan Ji, Hongtao Li, Mengyue Jing, Yang Gao, Yuting Liu, Sen Li, Guoming Xing, Yanfang Wang   +10 more
doaj   +1 more source

Hybridization between char species (Salvelinus alpinus and Salvelinus fontinalis): a fast track for novel allometric trajectories

Biology Open, 2018
Hybridization between closely related species can generate genetic and phenotypic variation, providing valuable biological material to assess the physiological impact of the structural or functional variability of different organs.
Bernard-Antonin Dupont Cyr, France Dufresne, Felix Christen, Véronique Desrosiers, Émilie Proulx, Nathalie R. Le François, Grant W. Vandenberg, Pierre U. Blier   +7 more
doaj   +1 more source

Assembly and Disassembly Planning by using Fuzzy Logic & Genetic Algorithms

, 2004
The authors propose the implementation of hybrid Fuzzy Logic-Genetic Algorithm (FL-GA) methodology to plan the automatic assembly and disassembly sequence of products. The GA-Fuzzy Logic approach is implemented onto two levels.
Galantucci, L. M., Percoco, G., Spina, R.   +2 more
core   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Cryptic diversity in southern African kelp

Scientific Reports
The southern coast of Africa is one of the few places in the world where water temperatures are predicted to cool in the future. This endemism-rich coastline is home to two sister species of kelps of the genus Ecklonia maxima and Ecklonia radiata, each ...
Pedro Madeira, Maggie M. Reddy, Jorge Assis, John J. Bolton, Mark D. Rothman, Robert J. Anderson, Lineekela Kandjengo, Anja Kreiner, Melinda A. Coleman, Thomas Wernberg, Olivier De Clerck, Frederik Leliaert, Salomão Bandeira, Abdul M. Ada, João Neiva, Gareth A. Pearson, Ester A. Serrão   +16 more
doaj   +1 more source

Association of CDKN2A/B Homozygous Deletion and Extent of Resection With Survival of Patients With WHO CNS5 Grade 4 Astrocytoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives WHO grade 4 astrocytomas are associated with poor prognosis, and their prognostic factors remain controversial. This study aimed to identify the prognostic factors and develop a management algorithm for these patients. Methods This study retrospectively included 151 CNS5 adult grade 4 astrocytomas from two medical centers.
Jiawei Cai, Guanglin Zhu, Qiu He, Chen Luo, Lingyun Zhuo, Xingfu Wang, Yiming Chen, Xiaoyong Chen, Wendong You, Jiaheng Xu, Yuanxiang Lin, Dezhi Kang, Shuai Wu, Zanyi Wu   +13 more
wiley   +1 more source