Results 51 to 60 of about 325,209 (298)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Expert consensus on microplastics and health core information

Zhongguo gonggong weisheng
Microplastics refer to plastic particles with a particle size of less than 5 millimeters, which have been recognized by some institutions as a new type of environmental pollutant.
Chinese Nutrition Society Hydration for Health Branch
doaj   +1 more source

Integrated Cobaloxime and Mesoporous Silica-Supported Ruthenium/Diamine Co-Catalysis for One-Pot Hydration/Reduction Enantioselective Sequential Reaction of Alkynes

Frontiers in Chemistry, 2021
This study developed a cost-efficient hydration/asymmetric transfer hydrogenation (ATH) process for the one-pot synthesis of valuable chiral alcohols from alkynes. During this process, the initial homogeneous cobaloxime-catalyzed hydration of alkynes was
Zeyang Liu, Yongjie Wang, Kaihong Liu, Shanshan Wang, Haocheng Liao, Yuanli Zhu, Baoming Hou, Chunxia Tan, Guohua Liu   +8 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Hydration-Facilitated Coordination Tuning of Metal–Organic Frameworks toward Water-Responsive Fluorescence and Proton Conduction

, 2022
Developing smart stimuli-responsive metal–organic frameworks (MOFs) with diversified induced readable signals is highly desirable; however, reported multimode responsive MOFs are always achieved under strong environmental stimulations, making it ...
Kaicong Cai (676872), Jiashuai Liang (11882862), Shengchang Xiang (1431784), Delin Li (494093), Yuanchao Lv (1660867), Zhile Xiong (8108189), Zhangjing Zhang (1431781)   +6 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Stakeholder perspectives of barriers and facilitators to enhancing hydration in elementary schools within a socio-ecological framework

Frontiers in Public Health
IntroductionAdequate hydration is vital for cognitive performance, fine motor skills, and visual attention, foundational for academic success. However, children spend a considerable portion of their waking hours at school, where they do not consume ...
Kristina L. Tatum, Kristina L. Tatum, Danyel I. Smith, Hsinling Sonya Hung, Hsinling Sonya Hung, Madison Weinstock, Shannon Rhodenhiser, Justine Blincoe, Alisa E. Brewer, Jessica Gokee LaRose, Tisha Erby, LaTriece Haskins, Kevin Starlings, Kevin Starlings, Katlyn Garr, Tegwyn H. Brickhouse, Melanie K. Bean, Hydration Community Advisory Board   +17 more
doaj   +1 more source

Beyond the "Spine of Hydration": Chiral SFG Spectroscopy Detects DNA First Hydration Shell and Base Pair Structures [PDF]

Experimental methods capable of selectively probing water at the DNA minor groove, major groove, and phosphate backbone are crucial for understanding how hydration influences DNA structure and function.
Victor, Batista, Elsa, Yan, Luis, Velarde, Matthew, Tremblay, Ethan, Perets, Pablo, Videla, Sharon, Hammes-Schiffer, Ty, Santiago, Daniel, Konstantinovsky   +8 more
core   +2 more sources

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source