Results 81 to 90 of about 384,591 (288)

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Energy analysis of hydraulic fracturing [PDF]

, 2009
In this paper, numerical simulations of circular boreholes under internal hydraulic pressure are carried out to investigate the energy transferred to the surrounding rock and the breakdown pressure.
Golshani, Aliakbar, Tran-Cong, Thanh
core   +1 more source

Receptogenesis in a Vascularized Robotic Embodiment

Advanced Science, EarlyView.
Functional augmentation of situated robots via ex novo hardware generation extends physical adaptability. Drawing inspiration from open circulatory systems for mass and function redistribution, this study presents a vascularized robotic composite exhibiting receptogenesis ‐ the on‐demand construction of sensors ‐ from internal fluid reserves based on ...
Kadri‐Ann Pankratov, Leonid Zinatullin, Hans Priks, Adele Metsniit, Urmas Johanson, Tarmo Tamm, Alvo Aabloo, Edoardo Sinibaldi, Indrek Must   +8 more
wiley   +1 more source

Investigation into Influences of Hydraulic Fracturing for Hard Rock Weakening in Underground Mines

Applied Sciences
The long overhanging distance of hard roofs and long-collapse steps induces a large area of suspension on the working face in underground coal mines, resulting in excessive pressure and deformation on the surrounding rocks of the adjacent roadway in the ...
Xu Cao, Saisai Wu, Qingyuan He
doaj   +1 more source

Self‐Assembly of Organic–Inorganic Copolymers Toward Bio‐Inspired Cementitious Composites

Advanced Science, EarlyView.
Organic–inorganic copolymerization of calcium silicate hydrate and thioctic acid produces a self‐organized nanocomposite inspired by the disordered collagen–mineral architecture of trabecular bone. The resulting material combines a compressive strength above 300 MPa with intrinsic physical reprocessibility, retaining over 80% of its strength and energy
Zonglin Xie, Suning Li, Fuwen Zhong, Gongkun Xiang, Mustapha Jamaa Garba, Yi Tian, Jun Wu, Zhiwu Yu, Qiang Yuan   +8 more
wiley   +1 more source

Optimization and application of hydraulic fracture propagation in carbonaceous and siliceous shales of marine-continental transition facies

Meikuang Anquan
Aiming at the differences in mechanical properties of carbonaceous and siliceous shale rocks in transitional facies, a hydraulic fracturing model was established using the finite element ABAQUS numerical simulation software. The influence of lithological
Bing LI, Haifeng ZHAO, Lingpeng MENG, Yalong HE, Jianjun WU   +4 more
doaj   +1 more source

Numerical Simulation of Hydraulic Fracturing in Earth and Rockfill Dam Using Extended Finite Element Method

Advances in Civil Engineering, 2018
Hydraulic fracturing is one of the most important factors affecting the safety of earth and rockfill dam. In this paper, the extended finite element method (XFEM) is used to simulate the hydraulic fracturing behavior in an actual high earth and rockfill ...
Enyue Ji, Zhongzhi Fu, Shengshui Chen, Jungao Zhu, Zhizhou Geng   +4 more
doaj   +1 more source

Experimental study of hydraulic fracturing in enhanced geothermal system

, 2018
The enhanced geothermal system is applied to develop the hot dry rock geothermal resource. The hot dry rock is dry and impermeable rock, like granite, in the depth of 3000~6000 meters; and its temperature is as high as 200 ℃.
Youn, Dong Joon, Jin, Y., Zeng, Y., Zhou, Z.   +3 more
core  

Mechanochemical Activation of a Bridged‐Exciplex Optical Force Probe

Advanced Science, EarlyView.
A bridged‐exciplex optical force probe is synthesized, switching from solvatochromic charge‐transfer emission in the latent state to intense locally excited emission upon activation. This dual photophysical response with additional changes in quantum yield and fluorescence lifetime enables precise environmental sensing and distinct optical readouts ...
Ronja Schumann, Andreas Bock, Felix Majer, Michael Baumann, Michael Olney‐Fraser, Lev Kazak, Fedor Jelezko, Alexander J. C. Kuehne, Robert Göstl   +8 more
wiley   +1 more source

Hydraulic fracturing and shale gas extraction [PDF]

Master of ScienceDepartment of Chemical EngineeringJames H. EdgarIn the past decade the technique of horizontal drilling and hydraulic fracturing has been improved so much that it has become a cost effective method to extract natural gas from shale ...
Klein, Michael
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