Results 11 to 20 of about 37,696 (242)

New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation

Molecules, 2015
New series of hydrazones 5–18 were synthesized, in good yields, by reacting 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carbohydrazide with differently substituted benzaldehyde.
Cristina Nastasă, Brîndușa Tiperciuc, Mihaela Duma, Daniela Benedec, Ovidiu Oniga   +4 more
doaj   +1 more source

Synthesis of indoles via alkylidenation of acyl hydrazides [PDF]

, 2009
Indoles have been synthesised via alkylidenation of acyl phenylhydrazides using phosphoranes and the Petasis reagent, followed by in situ thermal rearrangement of the product enehydrazines.
Commeureuc, A.G.J., EPSRC (Funder), Hisler, K., Murphy, J.A., WestCHEM (Funder), Zhou, S.Z.   +5 more
core   +1 more source

Crystal structure, Hirshfeld surface analysis and geometry optimization of 2-hydroxyimino-N-[1-(pyrazin-2-yl)ethylidene]propanohydrazide

Acta Crystallographica Section E: Crystallographic Communications, 2022
In the molecule of the title compound, C9H11N5O2, the oxime and hydrazide groups are situated in a cis-position in relation to the C—C bond linking the two functional groups.
Maksym O. Plutenko, Svitlana V. Shishkina, Oleg V. Shishkin, Vadim A. Potaskalov, Valentina A. Kalibabchuk   +4 more
doaj   +1 more source

Crystal structure of 2-cyano-N′-(cyclohexylidene)acetohydrazide

Acta Crystallographica Section E, 2014
In the title compound, C9H13N3O, the cyclohexylidene ring adopts a chair conformation and the bond-angle sum at the C atom linked to the N atom is 359.6°. The cyanoacetohydrazide grouping is close to planar (r.m.s. deviation for the non-H atoms = 0.031 Å)
William T. A. Harrison, Ola K. Al-Sakka, Daisy H. Fleita, Amina Saleh, Sara Salem   +4 more
doaj   +1 more source

Synthesis and Quantitative Structure–Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair and p53. [PDF]

, 2013
The antitumor prodrug Temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (EC 2.1.1.63, MGMT). Tumor
Arris C. E., Arrowsmith J., Barvaux V. A., Boberg F., Boyd M. R., Bunz F., Damera K., Darkes M. J. M., De K., Denny B. J., Dimitrios Pletsas, Dinca E. B., Elrashied A. E. Garelnabi, Garelnabi E. A. E., Hirose Y., Honnalli S. S., Judson P. L., Karran P., Karran P., Kotera M., Leteurtre F., Li Li, Liu L., McElhinney R. S., McGarrity J. F., Mladek A. C., Nishizuka S., Pletsas D., Richard T. Wheelhouse, Roger M. Phillips, Sarkaria J. N., Schmidt B. F., Schmiedekamp A., Shealy Y. F., Siddiqui A. A., Smith R. H., Stevens M. F. G., Svilar D., Wang Y., Wheelhouse R. T., Wheelhouse R. T., Zhang J., Zhang J.   +42 more
core   +1 more source

A CuAAC–Hydrazone–CuAAC Trifunctional Scaffold for the Solid-Phase Synthesis of Trimodal Compounds: Possibilities and Limitations

Molecules, 2015
We present a trifunctional scaffold designed for the solid-phase synthesis of trimodal compounds. This scaffold holds two alkyne arms in a free and TIPS-protected form for consecutive CuAAC (copper(I)-catalyzed azide–alkyne cycloaddition), one Fmoc ...
Benjamin Fabre, Jan Pícha, Václav Vaněk, Miloš Buděšínský, Jiří Jiráček   +4 more
doaj   +1 more source

Novel Indole-Based Analogs of Melatonin: Synthesis and in Vitro Antioxidant Activity Studies

Molecules, 2010
The aim of this study was to synthesize and examine possible in vitro antioxidant effects of indole-based melatonin analogue compounds. As a part of our ongoing study nineteen indole hydrazide/hydrazone derivatives were synthesized, characterized and ...
Hanif Shirinzadeh, Burcu Eren, Hande Gurer-Orhan, Sibel Suzen, Seçkin Özden   +4 more
doaj   +1 more source

N′-[(E)-4-Methoxybenzylidene]-2-(4-methylphenoxy)acetohydrazide

IUCrData, 2016
The title compound, C17H18N2O3, crystallizes with two independent molecules (A and B) in the asymmetric unit. The dihedral angle between the 4-methoxyphenyl ring and the toluene ring is 88.13 (10)° in molecule A and 61.47 (10)° in molecule B.
Seranthimata Samshuddin, S. Naveen, Dandavathi Arunkumar, A. Mahesha, N. K. Lokanath, Muneer Abdoh   +5 more
doaj   +1 more source

Clean Grinding Technique: A Facile Synthesis and In Silico Antiviral Activity of Hydrazones, Pyrazoles, and Pyrazines Bearing Thiazole Moiety against SARS-CoV-2 Main Protease (M^pro)

Molecules, 2020
A novel series of some hydrazones bearing thiazole moiety were generated via solvent-drop grinding of thiazole carbohydrazide 2 with various carbonyl compounds.
Sraa Abu-Melha, Mastoura M. Edrees, Sayed M. Riyadh, Mohamad R. Abdelaziz, Abdo A. Elfiky, Sobhi M. Gomha   +5 more
doaj   +1 more source

Synthesis and reactions of 1-amino-1,5,6,10b-tetrahydroimidazo[2,1-a]isoquinolin-2(3H)-ones [PDF]

, 2008
1-Amino-1,5,6,10b-tetrahydroimidazo[2,1-a]isoquinolin-2(3H)-ones, as previously unknown ring-annelated isoquinolines with a 3-aminoimidazolidin-4-one scaffold, were selectively prepared upon reacting 2-carbamoylmethyl- or 2-ethoxycarbonylmethyl-3,4 ...
De Kimpe, Norbert, Holzer, Wolfgang, Mangelinckx, Sven, Martynaitis, Vytas, Solovjova, Joana, Šačkus, Algirdas   +5 more
core   +2 more sources