Results 21 to 30 of about 96,758 (179)

Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Mutant isocitrate dehydrogenase (IDH) 2 “IDH2m” acquires a neo-enzymatic activity reducing α-ketoglutarate to an oncometabolite, D-2-hydroxyglutarate (2-HG). Three s-triazine series were designed and synthesised using enasidenib as a lead compound.
Ahmed F. Khalil, Tarek F. El-Moselhy, Eman A. El-Bastawissy, Rasha Abdelhady, Nancy S. Younis, Mervat H. El-Hamamsy   +5 more
doaj   +1 more source

Active site recovery and N-N bond breakage during hydrazine oxidation boosting the electrochemical hydrogen production

Nature Communications, 2023
Substituting hydrazine oxidation reaction for oxygen evolution reaction can result in greatly reduced energy consumption for hydrogen production, however, the mechanism and the electrochemical utilization rate of hydrazine oxidation reaction remain ...
Libo Zhu, Jian Huang, Ge Meng, Tiantian Wu, Chang Chen, Han Tian, Yafeng Chen, Fantao Kong, Ziwei Chang, Xiangzhi Cui, Jianlin Shi   +10 more
doaj   +1 more source

Preparation and characterization of bis-[1,3,5]triazinyl diazenes and their utilization as flame retardants in polypropylene films [PDF]

, 2014
A series of bis-[1,3,5]triazinyl diazenes and two metal complexes thereof were synthesized and tested as new flame retardants in polypropylene films. It was observed that electron withdrawing triazinyl ring substituents (i.e.
Aelmans, Aubert, Aubert, Aubert, Chantarasiri, Chen, Chigrinov, Chudgar, Dugave, Duliban, Huang, Huynh, Inoue, Inoue, Kandil, Koopman, Laoutid, Larkin, Li, Lin, Loew, Mikhailov, Milman, Morgan, Morgan, Nicolas, Oxley, Pawelec, Petredis, Ribeiro da Silva, Schartel, Singh, Skinner, Starnes, Tirri, Veen, Wilen, Yamanaka, Zhao, Zhong, Zilker   +40 more
core   +1 more source

Synthesis of antioxidant and antimicrobial bioactive compounds based on the quinoline-hydrazone and benzimidazole structure

Journal of Advanced Pharmaceutical Technology & Research, 2023
Quinoline and its derivatives are known to have various biological activities such as antibacterial and antioxidant. Therefore, this study aims to synthesize quinoline moiety from isatin and ethyl acetoacetate by Pfitzinger reaction under acidic ...
Antonius Herry Cahyana, Devin Halim, Laely Amaliyah   +2 more
doaj   +1 more source

Readily accessible sp3-rich cyclic hydrazine frameworks exploiting nitrogen fluxionality [PDF]

, 2020
Increased molecular complexity correlates with improved chances of success in the drug development process. Here, a strategy for the creation of sp3-rich, non-planar heterocyclic scaffolds suitable for drug discovery is described that obviates the need ...
Carson, Nessa, Clarkson, Guy J., Dean, Conor, Jones, Matthew L., Rajkumar, Sundaram, Roesner, Stefan, Shipman, Michael, Wills, Martin   +7 more
core   +1 more source

Palladium nanoparticles by electrospinning from poly(acrylonitrile-co-acrylic acid)-PdCl2 solutions. Relations between preparation conditions, particle size, and catalytic activity [PDF]

, 2004
Catalytic palladium (Pd) nanoparticles on electrospun copolymers of acrylonitrile and acrylic acid (PAN-AA) mats were produced via reduction of PdCl2 with hydrazine.
Basu B., Bronstein L., Bronstein L. M., Bönnemann H., Demir M. M., Doshi J., Forster J. F., Gui Z., Hedden R. C., Hirai H., Horswell S., Itoh H., Jia H., Ledaux M., Li Y. D., Sidorov S. N., Spatz J. P., Sulman E., Willis M., Wonterghem J., Yang Q. B., Yonezawa T.   +21 more
core   +3 more sources

Dimer/tetramer motifs determine amphiphilic hydrazine fibril structures on graphite

Beilstein Journal of Nanotechnology, 2012
Fibril structures are produced at a solvent–graphite interface by self-assembly of custom-designed symmetric and asymmetric amphiphilic benzamide derivatives bearing C10 aliphatic chains.
Loji K. Thomas, Nadine Diek, Uwe Beginn, Michael Reichling   +3 more
doaj   +1 more source

GaAs(111)A and B in hydrazine sulfide solutions : extreme polarity dependence of surface adsorption processes

, 2009
Chemical bonds formed by hydrazine-sulfide treatment of GaAs(111) were studied by synchrotron photoemission spectroscopy. At the B surface, the top arsenic atoms are replaced by nitrogen atoms, while GaAs(111)A is covered by sulfur, also bonded to ...
Berkovits, V. L., Chiaradia, P., Doyle, B. P., Nannarone, S., Paget, D., Rowe, A. C. H., Tereshchenko, O. E., Ulin, V. P.   +7 more
core   +1 more source

Micelles Mediated Zone Fluidics Method for Hydrazine Determination in Environmental Samples

Molecules, 2019
An automated flow method for the determination of hydrazine based on the concept of zone-fluidics has been developed. The analyte reacts under flow conditions with p-dimethylamino benzaldehyde (25 mmol L−1) in micellar medium (100 mmol L−1 ...
Theano D. Karakosta, Christophoros Christophoridis, Konstantinos Fytianos, Paraskevas D. Tzanavaras   +3 more
doaj   +1 more source

Organocatalytic cascade aza-Michael/hemiacetal reaction between disubstituted hydrazines and α,β-unsaturated aldehydes: Highly diastereo- and enantioselective synthesis of pyrazolidine derivatives

Beilstein Journal of Organic Chemistry, 2012
The catalytic synthesis of nitrogen-containing heterocycles is of great importance to medicinal and synthetic chemists, and also a challenge for modern chemical methodology.
Zhi-Cong Geng, Jian Chen, Ning Li, Xiao-Fei Huang, Yong Zhang, Ya-Wen Zhang, Xing-Wang Wang   +6 more
doaj   +1 more source