Metabolic bioactivation of antidepressants: advance and underlying hepatotoxicity. [PDF]
Drug Metab RevMany drugs that serve as first-line medications for the treatment of depression are associated with severe side effects, including liver injury. Of the 34 antidepressants discussed in this review, four have been withdrawn from the market due to severe ...
Khalil SM +3 more
europepmc +3 more sources
Crystal structure of(E)N{2[2(3chlorobenzylidene)hydrazinyl]-2-oxoethyl}-4-methylbenzenesulfonamide monohydrate [PDF]
, 2015 The molecule of the title compound, C16H16ClN3O3SH2O, is L-shaped being bent at the S atom; the S—N—C—C torsion angle is 132.0 (3). The central part of the molecule, C—C—N—N C, is almost linear, with the C—C—N—N and C—N—N C torsion angles being 174.1 ...
Purandara, H. +2 more
core +9 more sources
X-ray analysis of different starch granules [PDF]
, 1995 Crystal sizes and lattice distortion parameters for root, pulse and cereal starch granules have been determined using observed X-ray diffraction reflections by Fourier method.
Ali, S. Z. +4 more
core +1 more source
Synthesis and reactions of 1-amino-1,5,6,10b-tetrahydroimidazo[2,1-a]isoquinolin-2(3H)-ones [PDF]
, 2008 1-Amino-1,5,6,10b-tetrahydroimidazo[2,1-a]isoquinolin-2(3H)-ones, as previously unknown ring-annelated isoquinolines with a 3-aminoimidazolidin-4-one scaffold, were selectively prepared upon reacting 2-carbamoylmethyl- or 2-ethoxycarbonylmethyl-3,4 ...
De Kimpe, Norbert +5 more
core +2 more sources
In vitro assessment of antimicrobial, antioxidant, and cytotoxic properties of Saccharin-Tetrazolyl and-Thiadiazolyl derivatives: the simple dependence of the pH value on antimicrobial activity [PDF]
, 2019 The antimicrobial, antioxidant, and cytotoxic activities of a series of saccharin-tetrazolyl and -thiadiazolyl analogs were examined. The assessment of the antimicrobial properties of the referred-to molecules was completed through an evaluation of ...
Andrade, Joana M. +9 more
core +1 more source
Metabolic Effects of Oral Phenelzine Treatment on High-Sucrose-Drinking Mice [PDF]
, 2018 Phenelzine has been suggested to have an antiobesity effect by inhibiting de novo lipogenesis, which led us to investigate the metabolic effects of oral chronic phenelzine treatment in high-sucrose-drinking mice.
Carpéné, Christian +3 more
core +2 more sources
Molecular aspects of monoamine oxidase B [PDF]
, 2016 Monoamine oxidases (MAO) influence the monoamine levels in brain by virtue of their role in neurotransmitter breakdown. MAO B is the predominant form in glial cells and in platelets.
Ramsay, Rona Ruth
core +1 more source
Mechanisms of hepatocellular toxicity associated with new psychoactive synthetic cathinones [PDF]
, 2017 Synthetic cathinones are a new class of psychostimulant substances. Rarely, they can cause liver injury but associated mechanisms are not completely elucidated.
Krähenbühl, Stephan +2 more
core +1 more source
N1-benzenesulfonyl-2-pyrazoline hybrids in neurological disorders [PDF]
A novel series of 1,3,5-trisubstituted-2-pyrazolines (5a-5t) was prepared via Claisen Schmidt condensation, followed by heterocyclization with hydrazine hydrate, substitution of N1 hydrogen of 2-pyrazoline nucleus with 4-chlorobenzenesulfonylchloride ...
Paliwal, Sarvesh +3 more
core +1 more source
Phytocannabinoids as novel therapeutic agents in CNS disorders [PDF]
, 2012 The Cannabis sativa herb contains over 100 phytocannabinoid (pCB) compounds and has been used for thousands of years for both recreational and medicinal purposes.
Hill, Andrew J. +3 more
core +1 more source