Results 1 to 10 of about 2,947 (138)
Network-based drug repurposing for potential stroke therapy [PDF]
Computational and Structural Biotechnology Journal, 2023 Stroke is the leading cause of death and disability worldwide, with a growing number of incidences in developing countries. However, there are currently few medical therapies for this disease.
Qihui Wu +5 more
doaj +2 more sources
Enhancing immunotherapy efficacy in NSCLC through the combined use of phenelzine and Akkermansia muciniphila to regulate gut microbial metabolite 5-HIAA [PDF]
Journal for ImmunoTherapy of CancerBackground Improving the efficacy of anti-programmed death 1 (PD-1) monoclonal antibody (mAb) therapy remains a major challenge for cancer immunotherapy in non-small cell lung cancer (NSCLC). Gut microbial metabolites can influence immunotherapy efficacy.
Jie Zhao +18 more
doaj +2 more sources
PCLAF-DREAM drives alveolar cell plasticity for lung regeneration [PDF]
Nature CommunicationsCell plasticity, changes in cell fate, is crucial for tissue regeneration. In the lung, failure of regeneration leads to diseases, including fibrosis. However, the mechanisms governing alveolar cell plasticity during lung repair remain elusive.
Bongjun Kim +14 more
doaj +2 more sources
Neuroprotection by acrolein sequestration through exogenously applied scavengers and endogenous enzymatic enabling strategies in mouse EAE model [PDF]
Scientific ReportsWe have previously shown that the pro-oxidative aldehyde acrolein is a critical factor in MS pathology. In this study, we found that the acrolein scavenger hydralazine (HZ), when applied from the day of induction, can suppress acrolein and alleviate ...
Jonathan Tang +4 more
doaj +2 more sources
Biomarker-driven drug repurposing for NAFLD-associated hepatocellular carcinoma using machine learning integrated ensemble feature selection [PDF]
Frontiers in BioinformaticsThe incidence of non-alcoholic fatty liver disease (NAFLD), encompassing the more severe non-alcoholic steatohepatitis (NASH), is rising alongside the surges in diabetes and obesity.
Subhajit Ghosh +2 more
doaj +2 more sources
Transcranial magnetic stimulation–associated mania with psychosis: A case report [PDF]
Mental Health Clinician, 2021 Transcranial magnetic stimulation (TMS) is a noninvasive procedure used in the treatment of depression. We observed TMS-associated mania with psychotic symptoms in a 55-year-old male diagnosed with MDD and generalized anxiety disorder without history of ...
Knox Erin D. PharmD, BCPP +1 more
doaj +1 more source
Frontiers in Oncology, 2022 ObjectiveLysine-Specific Demethylase-1 (LSD1) is overexpressed in breast cancer cells and facilitate mesenchymal properties which may contribute to therapeutic resistance and cancer progression.
Thiru Prasanna +18 more
doaj +1 more source
Anaesthesia, 1986 Summary A 46‐year‐old female with severe phenelzine poisoning was managed successfully by alpha blockade and fluid loading, with the aid of invasive haemodynamic monitoring. The pathophysiology was documented, showing elevated plasma and urinary catecholamines, cardiovascular abnormalities and a contracted blood volume.
F X, Breheny, G J, Dobb, G M, Clarke
openaire +2 more sources
Frontiers in Pharmacology, 2022 MAOIs, a well-established class of antidepressant that operate through the inhibition of monoamine oxidase to increase available serotonin, have recently been identified as a surprisingly effective candidate for the circumvention of tumor-induced immune ...
James Brown +14 more
doaj +1 more source
Monoamine oxidase inhibitors and neuroprotective mechanisms
Psychiatry and Clinical Psychopharmacology, 2021 There has been a resurgence of interest in recent years in monoamine oxidase inhibitors, primarily because of the demonstrated neuroprotective and/ or neurorescue properties of several of these drugs in a variety of toxic situations in vivo and in vitro.
Glen Baker +4 more
doaj +1 more source