Results 1 to 10 of about 3,571 (163)

Transcranial magnetic stimulation–associated mania with psychosis: A case report [PDF]

Mental Health Clinician, 2021
Transcranial magnetic stimulation (TMS) is a noninvasive procedure used in the treatment of depression. We observed TMS-associated mania with psychotic symptoms in a 55-year-old male diagnosed with MDD and generalized anxiety disorder without history of ...
Knox Erin D. PharmD, BCPP, Bota Robert G. MD   +1 more
doaj   +3 more sources

A Phase 1 Proof of Concept Study Evaluating the Addition of an LSD1 Inhibitor to Nab-Paclitaxel in Advanced or Metastatic Breast Cancer (EPI-PRIMED) [PDF]

Frontiers in Oncology, 2022
ObjectiveLysine-Specific Demethylase-1 (LSD1) is overexpressed in breast cancer cells and facilitate mesenchymal properties which may contribute to therapeutic resistance and cancer progression.
Thiru Prasanna, Thiru Prasanna, Thiru Prasanna, Laeeq Malik, Laeeq Malik, Robert D. McCuaig, Wen Juan Tu, Fan Wu, Pek Siew Lim, Abel H. Y. Tan, Jane E. Dahlstrom, Jane E. Dahlstrom, Philip Clingan, Eugene Moylan, Jeremy Chrisp, David Fuller, Sudha Rao, Desmond Yip, Desmond Yip   +18 more
doaj   +2 more sources

Enhancing immunotherapy efficacy in NSCLC through the combined use of phenelzine and Akkermansia muciniphila to regulate gut microbial metabolite 5-HIAA [PDF]

Journal for ImmunoTherapy of Cancer
Background Improving the efficacy of anti-programmed death 1 (PD-1) monoclonal antibody (mAb) therapy remains a major challenge for cancer immunotherapy in non-small cell lung cancer (NSCLC). Gut microbial metabolites can influence immunotherapy efficacy.
Jie Zhao, Yujie Wei, Lili Zhu, Chunwei Li, Lifeng Li, Yuanyuan Zheng, Yahao Ge, Pu Yu, Shilong Sun, Longhao Wang, Kang Cui, Yuchao Ding, Zhibo Shen, Yaqi Yang, Yiqiong Song, Ke Chao, Yixing Zhang, Wenxuan Ji, Gautam Sethi   +18 more
doaj   +2 more sources

PCLAF-DREAM drives alveolar cell plasticity for lung regeneration [PDF]

Nature Communications
Cell plasticity, changes in cell fate, is crucial for tissue regeneration. In the lung, failure of regeneration leads to diseases, including fibrosis. However, the mechanisms governing alveolar cell plasticity during lung repair remain elusive.
Bongjun Kim, Yuanjian Huang, Kyung-Pil Ko, Shengzhe Zhang, Gengyi Zou, Jie Zhang, Moon Jong Kim, Danielle Little, Lisandra Vila Ellis, Margherita Paschini, Sohee Jun, Kwon-Sik Park, Jichao Chen, Carla Kim, Jae-Il Park   +14 more
doaj   +2 more sources

Neuroprotection by acrolein sequestration through exogenously applied scavengers and endogenous enzymatic enabling strategies in mouse EAE model [PDF]

Scientific Reports
We have previously shown that the pro-oxidative aldehyde acrolein is a critical factor in MS pathology. In this study, we found that the acrolein scavenger hydralazine (HZ), when applied from the day of induction, can suppress acrolein and alleviate ...
Jonathan Tang, Anna Alford, Gary Leung, Melissa Tully, Riyi Shi   +4 more
doaj   +2 more sources

Biomarker-driven drug repurposing for NAFLD-associated hepatocellular carcinoma using machine learning integrated ensemble feature selection [PDF]

Frontiers in Bioinformatics
The incidence of non-alcoholic fatty liver disease (NAFLD), encompassing the more severe non-alcoholic steatohepatitis (NASH), is rising alongside the surges in diabetes and obesity.
Subhajit Ghosh, Sukhen Das Mandal, Subarna Thakur   +2 more
doaj   +2 more sources

Monoamine oxidase inhibitors and neuroprotective mechanisms

Psychiatry and Clinical Psychopharmacology, 2021
There has been a resurgence of interest in recent years in monoamine oxidase inhibitors, primarily because of the demonstrated neuroprotective and/ or neurorescue properties of several of these drugs in a variety of toxic situations in vivo and in vitro.
Glen Baker, Dmitriy Matveychuk, Erin M. MacKenzie, Serdar Dursun, Darrell D. Mousseau   +4 more
doaj   +1 more source

Nanoformulation improves antitumor efficacy of MAOI immune checkpoint blockade therapy without causing aggression-related side effects

Frontiers in Pharmacology, 2022
MAOIs, a well-established class of antidepressant that operate through the inhibition of monoamine oxidase to increase available serotonin, have recently been identified as a surprisingly effective candidate for the circumvention of tumor-induced immune ...
James Brown, Zhe Li, Xi Wang, Yu Jeong Kim, Yu-Chen Wang, Yanning Zuo, Yanning Zuo, Weizhe Hong, Weizhe Hong, Pin Wang, Bo Li, Lili Yang, Lili Yang, Lili Yang, Lili Yang   +14 more
doaj   +1 more source

Evolution of ideas about the risk of tyramine syndrome developing during therapy with irreversible non-selective monoamine oxidase inhibitors (to the 70th anniversary of the first use of this group of antidepressants)

Неврология, нейропсихиатрия, психосоматика, 2022
We describe the history of studying of the problem of tyramine syndrome during the treatment with antidepressants, irreversible non-selective monoamine oxidase inhibitors. Data on clinical observations are presented.
D. S. Danilov, M. Yu. Brovko
doaj   +1 more source

The History of Irreversible Non-Selective MAOI Antidepressants in Russia (for their 70th Anniversary)

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2023
The history of irreversible non-selective MAOI antidepressants in the USSR and Russia is systemized. The history of representatives’ appearance is described. The history of the study of pharmacological effects is highlighted.
D. S. Danilov
doaj   +1 more source