Results 21 to 30 of about 3,571 (163)

Role of MAOI drugs as triggers of manic episodes in bipolar disorders: A case report and a narrative review

European Psychiatry, 2022
Introduction Use of Monoamine Oxidase Inhibitors (MAOIs) has experimented an important reduction in recent years, being replaced by other antidepressant drugs (ADs) associated with a better safety profile.
L. Olivier Mayorga, L. Ilzarbe, H. Andreu Gracia, L. Bueno Sanya, O. De Juan Viladegut, P. Barrio   +5 more
doaj   +1 more source

Phenelzine produces subsensitivity to nicotine [PDF]

, 1993
Dilsaver, Steven C., Meenatshisundanan Hariharan, Robin K. Davidson: Phenelzine Produces Subsensitivity to Nicotine. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1993, 17(5): 847-860. 1. 1.
Davidson, Robin K., Dilsaver, Steven C., Hariharan, Meenatshisundanan   +2 more
core   +1 more source

Amino acid and biogenic amine concentrations during experimental autoimmune encephalomyelitis and the disease-modifying effects of phenelzine treatment [PDF]

, 2011
The project described in this thesis began with a broad analysis of the changes to amino acid and biogenic amine concentrations in the central nervous system (CNS) during experimental autoimmune encephalomyelitis (EAE) in mice, an animal model of ...
Musgrave, Travis
core   +1 more source

Opipramol Inhibits Lipolysis in Human Adipocytes without Altering Glucose Uptake and Differently from Antipsychotic and Antidepressant Drugs with Adverse Effects on Body Weight Control

Pharmaceuticals, 2020
Treatment with several antipsychotic drugs exhibits a tendency to induce weight gain and diabetic complications. The proposed mechanisms by which the atypical antipsychotic drug olanzapine increases body weight include central dysregulations leading to ...
Christian Carpéné, Francisco Les, Josep Mercader, Saioa Gomez-Zorita, Jean-Louis Grolleau, Nathalie Boulet, Jessica Fontaine, Mari Carmen Iglesias-Osma, Maria José Garcia-Barrado   +8 more
doaj   +1 more source

Functional Characterization of the Effects of N-acetyltransferase 2 Alleles on N-acetylation of Eight Drugs and Worldwide Distribution of Substrate-Specific Diversity

Frontiers in Genetics, 2021
Variability in the enzymatic activity of N-acetyltransferase 2 (NAT2) is an important contributor to interindividual differences in drug responses. However, there is little information on functional differences in N-acetylation activities according to ...
Koya Fukunaga, Ken Kato, Takuji Okusaka, Takeo Saito, Masashi Ikeda, Teruhiko Yoshida, Hitoshi Zembutsu, Nakao Iwata, Taisei Mushiroda   +8 more
doaj   +1 more source

Novel properties of the multifaceted drug phenelzine and its metabolite β-phenylethylidenehydrazine [PDF]

, 2015
Phenelzine is a monoamine oxidase (MAO) inhibitor that has been used for the treatment of depression and anxiety disorders since the 1960s. In recent years, there has been renewed interest in this drug following reports of its neuroprotective properties ...
Matveychuk, Dmitriy
core   +1 more source

Efficacy and tolerability of tranylcypromine versus phenelzine: A double-blind study in antidepressant- refractory depressed inpatients

, 2004
Item does not contain fulltextBackground: The aim of this study was to examine whether phenelzine is a suitable alternative to tranylcypromine in antidepressant-resistant depression.
Birkenhäger, T.K. (Tom), Broek, W.W. (Walter) van den, Bruijn, J.A. (Jan), Moleman, P. (Peter), Mulder, P.G.H. (Paul), Mulder, Paul G., Birkenhäger, Tom K., Bruijn, Jan A., Moleman, Peter, Van Den Broek, Walter W.; id_orcid, Tom K. Birkenhäger, Paul G. Mulder, Birkenhäger, T.K., Bruijn, J.A., Peter Moleman, Walter W. van den Broek, Jan A. Bruijn, Mulder, P.G.H., Moleman, P., Broek, W.W. van den   +19 more
core   +2 more sources

LSD1 inhibitors for cancer treatment: Focus on multi-target agents and compounds in clinical trials

Frontiers in Pharmacology, 2023
Histone lysine-specific demethylase 1 (LSD1/KDM1A) was first identified in 2004 as an epigenetic enzyme able to demethylate specific lysine residues of histone H3, namely H3K4me1/2 and H3K9me1/2, using FAD as the cofactor.
Beatrice Noce, Elisabetta Di Bello, Rossella Fioravanti, Antonello Mai, Antonello Mai   +4 more
doaj   +1 more source

The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer

Nature Communications, 2020
Castration resistant prostate cancer patients treated with enzalutamide may develop resistance to the drug. Here, the authors report that monoamine oxidase-A expression is increased in these resistant tumors and that the antidepressants phenelzine ...
Keliang Wang, Jie Luo, Shuyuan Yeh, Bosen You, Jialin Meng, Philip Chang, Yuanjie Niu, Gonghui Li, Changxue Lu, Yezi Zhu, Emmanuel S. Antonarakis, Jun Luo, Chi-Ping Huang, Wanhai Xu, Chawnshang Chang   +14 more
doaj   +1 more source

Antidepressants and movement disorders: a postmarketing study in the world pharmacovigilance database

BMC Psychiatry, 2020
Background Antidepressants-induced movement disorders are rare and imperfectly known adverse drug reactions. The risk may differ between different antidepressants and antidepressants’ classes.
Alexis Revet, François Montastruc, Anne Roussin, Jean-Philippe Raynaud, Maryse Lapeyre-Mestre, Thi Thu Ha Nguyen   +5 more
doaj   +1 more source