Medicines for Anxiety: A Hundred Years of Tranquillity and More to Come? [PDF]
Hum PsychopharmacolHuman Psychopharmacology: Clinical and Experimental, Volume 41, Issue 2, March 2026.
Nutt D.
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Network-based drug repurposing for potential stroke therapy [PDF]
Computational and Structural Biotechnology Journal, 2023 Stroke is the leading cause of death and disability worldwide, with a growing number of incidences in developing countries. However, there are currently few medical therapies for this disease.
Qihui Wu +5 more
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Correction to "The MAO-B Inhibitor Selegiline Reduces the Viability of Different Prostate Cancer Cell Lines and Enhances the Effects of Anti-Androgen and Cytostatic Agents". [PDF]
Pharmacol Res PerspectPharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.
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Enhancing immunotherapy efficacy in NSCLC through the combined use of phenelzine and Akkermansia muciniphila to regulate gut microbial metabolite 5-HIAA [PDF]
Journal for ImmunoTherapy of CancerBackground Improving the efficacy of anti-programmed death 1 (PD-1) monoclonal antibody (mAb) therapy remains a major challenge for cancer immunotherapy in non-small cell lung cancer (NSCLC). Gut microbial metabolites can influence immunotherapy efficacy.
Jie Zhao +18 more
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PCLAF-DREAM drives alveolar cell plasticity for lung regeneration [PDF]
Nature CommunicationsCell plasticity, changes in cell fate, is crucial for tissue regeneration. In the lung, failure of regeneration leads to diseases, including fibrosis. However, the mechanisms governing alveolar cell plasticity during lung repair remain elusive.
Bongjun Kim +14 more
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Characterizing treatment initiation with central nervous system-active polypharmacy among adults with dementia. [PDF]
Alzheimers DementAbstract INTRODUCTION Central nervous system (CNS) –active polypharmacy, defined as concurrent use of antidepressants, antipsychotics, anti‐seizure medications, benzodiazepines, nonbenzodiazepine benzodiazepine receptor agonists, opioids, or skeletal muscle relaxants for ≥ 31 consecutive days, poses significant risks patients with dementia.
Maust DT +9 more
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Neuroprotection by acrolein sequestration through exogenously applied scavengers and endogenous enzymatic enabling strategies in mouse EAE model [PDF]
Scientific ReportsWe have previously shown that the pro-oxidative aldehyde acrolein is a critical factor in MS pathology. In this study, we found that the acrolein scavenger hydralazine (HZ), when applied from the day of induction, can suppress acrolein and alleviate ...
Jonathan Tang +4 more
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Biomarker-driven drug repurposing for NAFLD-associated hepatocellular carcinoma using machine learning integrated ensemble feature selection [PDF]
Frontiers in BioinformaticsThe incidence of non-alcoholic fatty liver disease (NAFLD), encompassing the more severe non-alcoholic steatohepatitis (NASH), is rising alongside the surges in diabetes and obesity.
Subhajit Ghosh +2 more
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Transcranial magnetic stimulation–associated mania with psychosis: A case report [PDF]
Mental Health Clinician, 2021 Transcranial magnetic stimulation (TMS) is a noninvasive procedure used in the treatment of depression. We observed TMS-associated mania with psychotic symptoms in a 55-year-old male diagnosed with MDD and generalized anxiety disorder without history of ...
Knox Erin D. PharmD, BCPP +1 more
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Frontiers in Oncology, 2022 ObjectiveLysine-Specific Demethylase-1 (LSD1) is overexpressed in breast cancer cells and facilitate mesenchymal properties which may contribute to therapeutic resistance and cancer progression.
Thiru Prasanna +18 more
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