Tobacco Induced Diseases, 2018 Background Current smoking cessation methods are primarily based on the theory that nicotine is the principal addicting compound overlooking the contribution of the monoamine oxidase inhibitors present in tobacco. Our study tests the hypothesis that the
Claude A. Curran +4 more
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A Case of the Serotonin Syndrome Secondary to Phenelzine Monotherapy at Therapeutic Dosing
Case Reports in Medicine, 2015 A 27-year-old Caucasian female with a history of depression was admitted to our local hospital with vague events that occurred a day before. This included an episode of dysarthria, and unsteadiness, followed by feeling generally unwell.
A. Malik, N. Junglee
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Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer [PDF]
Frontiers in Immunology, 2019 Macrophages play an important role in regulating the tumor microenvironment (TME). Here we show that classical (M1) macrophage polarization reduced expression of LSD1, nuclear REST corepressor 1 (CoREST), and the zinc finger protein SNAIL.
Abel H. Y. Tan +7 more
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Pathogens, 2021 Non-typhoidal Salmonella ingeniously scavenges energy for growth from tyramine (TYR) and d-glucuronic acid (DGA), both of which occur in the host as the metabolic byproducts of the gut microbial metabolism. A critical first step in energy scavenging from
Raquel Burin, Devendra H. Shah
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Exploring the Neuropharmacological Potential of Ligustrum sinense Relevant to Parkinson's Disease: In Vivo and In Silico Study. [PDF]
Chem BiodiversLigustrum sinense (L. sinense) leaf extract exhibited moderate antioxidant activity (DPPH IC50 = 73.56 ± 2.18 µg/mL) and was evaluated for neuropharmacological effects at 200 and 400 mg/kg using elevated plus maze, open‐field, hole‐cross, and hole‐board tests.
Das S +9 more
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Patients With Atypical Symptoms of Depression Respond Better to Lithium Augmentation Than Patients Without Atypical Symptoms. [PDF]
Acta Psychiatr ScandABSTRACT Introduction Understanding the differences in treatment response between subtypes of major depressive disorder (MDD) may help to prevent lengthy trial‐and‐error processes by identifying effective treatment options. The aim of the study was to investigate the impact of atypical features of MDD (MDD‐A) on the response to lithium augmentation (LA)
Buchbauer H +8 more
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Psychometric Properties of the Choosing Wisely Questions in a Large Psychiatric Sample. [PDF]
Int J Methods Psychiatr ResABSTRACT Objectives The Choosing Wisely Questions (CWQ) support shared decision‐making and aim to reduce low‐value care, but their psychometric properties remain unclear. This study evaluated the structural validity, reliability, and item characteristics of the Swedish CWQ in a psychiatric sample.
Bengtsson J +6 more
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Medicines for Anxiety: A Hundred Years of Tranquillity and More to Come? [PDF]
Hum PsychopharmacolHuman Psychopharmacology: Clinical and Experimental, Volume 41, Issue 2, March 2026.
Nutt D.
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Network-based drug repurposing for potential stroke therapy
Computational and Structural Biotechnology Journal, 2023 Stroke is the leading cause of death and disability worldwide, with a growing number of incidences in developing countries. However, there are currently few medical therapies for this disease.
Qihui Wu +5 more
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Clomipramine Induced Extrapyramidal Symptoms: A Case Series [PDF]
Journal of Clinical and Diagnostic Research, 2023 Extra Pyramidal Symptoms (EPS) are a group of symptoms that include dystonia, bradykinesia, tremor, akathisia, and tardive dyskinesia. They are caused by the blockage of D2 receptors in the nigro-striatal pathway and the imbalanced acetyl choline ...
Disha Mukherjee +2 more
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