Results 101 to 110 of about 2,042 (119)

Deaminative cross-coupling of amines by boryl radical β-scission. [PDF]

Nature
Zhang Z, Lonardi G, Sephton T, Guersoy YC, Stavagna C, Lenardon GVA, Bietti M, Leonori D.   +7 more
europepmc   +1 more source

Recent advancement in prevention against hepatotoxicity, molecular mechanisms, and bioavailability of gallic acid, a natural phenolic compound: challenges and perspectives. [PDF]

Front Pharmacol
Chen P, Zou F, Liu W.
europepmc   +1 more source

Development of Novel Sulfonamide-Based Pyrazole-Clubbed Pyrazoline Derivatives: Synthesis, Biological Evaluation, and Molecular Docking Study. [PDF]

ACS Omega
Zala M, Vora JJ, Khedkar VM, Almalki AH, Tivari S, Jatvada R.   +5 more
europepmc   +1 more source

Design, synthesis, molecular docking and pharmacological evaluation of some thiadiazole based nipecotic acid derivatives as a potential anticonvulsant and antidepressant agents. [PDF]

3 Biotech
Singh GK, Kumari B, Das N, Zaman K, Prasad P, Singh RB.   +5 more
europepmc   +1 more source

Choline chloride/urea as a green and efficient deep eutectic solvent in three-component and four-component synthesis of novel pyrazole and pyrano[2,3-c] pyrazole derivatives with antibacterial and antifungal activity. [PDF]

Front Chem
Habeeb Naser I, Thoulfikar A Alamir H, Al-Shukarji AH, Ahmed BA, Qassem TA, Kamal M, Almeleebia TM, Alwaily ER, Hasan Kadhum E, Alawadi A, Alsalamy A.   +10 more
europepmc   +1 more source

Role of alpha-synuclein in the regulation of dopamine neurotransmission in the striatum [PDF]

Chadchankar, Heramb
core  

DNA damage caused by antidepressant hydrazines and related drugs

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1968
Abstract Antidepressant hydrazines (e.g. isocarboxazid, nialamide, and phenelzine) and the anti-tubercle agent isoniazid react with oxygen, producing hydrogen peroxide. The radicals formed in this reaction inactivate DNA. These compounds, as well as carbamates that can be enzymatically converted to reactive N-hydroxycarbamates, may therefore cause ...
E, Freese, S, Sklarow, E B, Freese
openaire   +3 more sources

Effect of acylation with eleostearic acids on the monoamine oxidase inhibitory potency of some hydrazine antidepressants in mice

Journal of Medicinal Chemistry, 1975
The effect of incorporation of an eleostearoyl group into molecules of aralkylhydrazines on their monoamine oxidase inhibitory potency was investigated in vitro and in vivo. The results showed that on a molar basis the hydrazides possessed an in vitro potency lower than and an in vivo potency and acute toxicity comparable to those of the corresponding ...
S Y, Hsu, C L, Huang, I W, Waters
openaire   +3 more sources

Genotoxic activity of five antidepressant hydrazines in a battery ofin vivoandin vitroshort‐term tests

Journal of Toxicology and Environmental Health, 1982
Five antidepressant agents (monoamine oxidase inhibitors) having a hydrazino group--phenelzine, nialamide, mebanazine, isocarboxazid, and iproniazid--were assayed in four in vivo or in vitro short-term tests predictive of the potential carcinogenicity of chemicals. (1) All the compounds tested except iproniazid, produced DNA fragmentation, as evaluated
BRAMBILLA, GIOVANNI, CAVANNA, MARCO, P. FAGGIN, PINO, ALBIANA, ROBBIANO, LUIGI, BENNICELLI, CARLO, ZANACCHI, PATRIZIA, CAMOIRANO, ANNA FIORENZA, DE FLORA, SILVIO   +8 more
openaire   +4 more sources

HYDRAZINE ANTIDEPRESSANTS AND ISONIAZID : POTENTIAL CARCINOGENS

The Lancet, 1971
H S, Rosenkranz, H S, Carr
openaire   +3 more sources