Results 31 to 40 of about 2,042 (119)

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects

Angewandte Chemie, Volume 137, Issue 27, July 1, 2025.
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka, Yusuke Yano, Nozomi Hara, Chihiro Sadamoto, Andres D. Maturana, Masaki Kita   +5 more
wiley   +1 more source

Solid phase extraction of biogenic amines using immobilized new hydrazone ligands. [PDF]

, 2011
Dalam kajian ini, sebatian hidrazin dan hidrazid melalui tindak balas kondensasi dengan keton dan terbitan berbeza aldehid menghasilkan hidrazon sepadan yang dijangkakan. Kesemua ligan yang dipisahkan memperolehi hasil yang memuaskan (82-94 %).
Alfergani, Abdassalam Abdelhafiz
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Assessment of enzyme inhibition : a review with examples from the development of monoamine oxidase and cholinesterase inhibitory drugs [PDF]

, 2017
Both authors are grateful for the collaborations on multi-target drugs facilitated by COST Action CM1103 (2011-2015).The actions of many drugs involve enzyme inhibition.
Ramsay, Rona R., Tipton, Keith F.
core   +1 more source

Novel Quinazolinones Active against Multidrug‐Resistant Mycobacterium Tuberculosis: Synthesis, Antimicrobial Evaluation, and in Silico Exploration of Penicillin‐Binding Protein 1A as a Potential Target

ChemMedChem, Volume 20, Issue 13, July 1, 2025.
Quinazolinone‐based compounds emerge as potent antimycobacterial agents, showing low minimum inhibitory concentrations against drug‐resistant Mycobacterium tuberculosis. Molecular modeling uncovers a novel allosteric site in PonA1 targeted by these derivatives.
Marek Kerda, Daria Nawrot, Petr Šlechta, Miroslav Domanský, Asal Askari, Hanieh Kamangar, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Ingrid Hlbočanová, Miloslav Macháček, Matteo Mori, Fiorella Meneghetti, Martin Doležal, Jan Zitko, Ghada Bouz   +15 more
wiley   +1 more source

Advances in Metal‐Free Transamidation: A Sustainable Approach to Amide Bond Formation

Chemistry – An Asian Journal, Volume 20, Issue 12, June 16, 2025.
This review highlights the recent developments of transamidation reactions under metal‐free reaction conditions. Various amines including weak nucleophilic amines such as aromatic amines have been used to achieve the transamidation reactions under mild and relatively green reaction conditions. Abstract The amide functionalities are a crucial functional
Niharan Sivaraj, Toshifumi Dohi, Fateh V. Singh   +2 more
wiley   +1 more source

Synthesis and antimicrobial evaluation of some ethoxyphthalimide derivatives of 3-(substitutedphenyl)-4-methyl-3a, 6-dihydropyrazolo[3,4-c]pyrazol-2(3H)-yl(pyridin-3-yl)methanone [PDF]

, 2010
5-Methyl-2,4-dihydro-3H-pyrazol-3-one (1) reacted with substituted benzaldehydes (2a-d) in the presence of anhydrous sodium acetate to gave corresponding 4-arylidene-5-methyl-2,4-dihyro-3H-pyrazol-3-ones (3a-d).
Dangi, Raja, Hussain, Nasir, Joshi, Ajit, Talesara, G.   +3 more
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Design, Synthesis, and Antibacterial Evaluation of Pyrazole Pyrimidine Hybrids: Integrative In Vitro and In Silico Studies

ChemistrySelect, Volume 10, Issue 17, May 5, 2025.
This study synthesizes novel pyrimidine–pyrazole hybrids and evaluates their antimicrobial activity against bacterial pathogens by targeting penicillin‐binding protein 3 (PBP3). Several compounds show significant activity against E. faecium. Docking studies reveal strong binding with HMG‐CoA synthase, while in silico pharmacokinetic predictions ...
Suresh Choppadandi, Divya Vemula, Nagaraju Kerru, Vasundhra Bhandari, Chilukoti Srilakshmi   +4 more
wiley   +1 more source

Design, synthesis and anticonvulsant activity of some new 5,7-dibromoisatin semicarbazone derivatives [PDF]

, 2013
A series of 5,7-dibromoisatin semicarbazones have been synthesized in good yield, involving aryl urea and aryl semicarbazide formation. The structures of the synthesized compounds were confirmed on the basis of their spectral data. All the compounds were
Kumar, Dheeraj, Kumar, Rajeev, Roy, R. K., Sharma, Vijay Kumar, Singh, Amar Deep, Singh, Hariram, Singh, Tejendra   +6 more
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Studies on synthesis of pyrazole from dibromo and hydrazine compounds. [PDF]

, 2021
Depression has become the fourth leading case for mortality and morbidity in the world. It is a leading cause of disability worldwide and is a major contributor to the overall global burden of disease. Current treatments of depression are inadequate, and
Trivedi, Riya
core   +1 more source

Nitrocyclopropanes as Valuable Building Blocks in Organic Synthesis and Biology: Exploring the Origin of the Nitro Group

Chemistry – A European Journal, Volume 31, Issue 20, April 4, 2025.
This review summarizes the synthetic methodologies of the nitro‐substituted Donor‐Acceptor cyclopropanes (NCPs). Particularly from nitroalkenes including the Michael Initiated Ring Closure and the Oxidative Ring Closure of Michael Adducts, from Diazo Compounds bearing Nitro Group, from Nitromethane and its Derivatives; and after Oxidation of ...
Andriani G. Chaidali, Michael A. Terzidis, Ioannis N. Lykakis   +2 more
wiley   +1 more source