Results 171 to 180 of about 31,731 (271)

Thermally Bistable Stiff Stilbene Photoswitches and Polymer Applications

The Chemical Record, Volume 26, Issue 6, June 2026.
Thermally stable photoswitches offer new opportunities for controlling polymer structures and functions under nonequilibrium conditions. This Personal Account highlights stiff stilbene (SS) and sterically hindered stiff stilbene (HSS) photoswitches, which combine large structural changes with exceptional thermal bistability.
Keiichi Imato
wiley   +1 more source

Remote Stereocontrol in Aryl/Alkyl C-H Insertion Reactions of Rhodium Carbenes: Assembly of Pseudorigidols A and B. [PDF]

Org Lett
Ung L, Dishman SN, Zhang S, Fettinger JC, Shaw JT.   +4 more
europepmc   +1 more source

Senescent BMSC‐Derived Thbs1 Drives Inflammaging and Impairs Bone Regeneration by Suppressing PINK1/Parkin‐Mediated Mitophagy in Macrophages

Aging Cell, Volume 25, Issue 6, June 2026.
Aging BMSC‐derived Thbs1 activates the macrophage TGF‐β/Smad3 pathway to transcriptionally repress Pink1, impairing mitophagy and causing mitochondrial ROS accumulation. This redox imbalance drives M1 polarization and IL‐6 secretion. IL‐6 feeds back to BMSCs via the JAK/STAT3 pathway to inhibit osteogenesis and upregulate Thbs1, establishing a self ...
Yifeng Xing, Jingjing Su, Yanjun Lin, Nengwen Huang, Sihui Zhang, Yuwei Zhou, Jie Lu, Weiping Chen, Kaixun He, Wenxiu Yuan, Yang Li, Geyuan Zheng, Pengyuan Hu, Dong Wu, Yanjing Ou, Jiang Chen   +15 more
wiley   +1 more source

<i>C</i>₃-Symmetric Photoresponsive Chiral Dopants Based on Tribenzotriquinacene. [PDF]

J Am Chem Soc
Balamut B, Bala I, Benke BP, Jose J, Mastalerz M, Aprahamian I.   +5 more
europepmc   +1 more source

Cruzain Inhibitors for Chagas Disease: Anticorrelated Optimisation Landscapes and the Multiparametric Path to Clinical Candidates

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Three decades of cruzain‐targeted drug discovery have yielded 215 sub‐micromolar inhibitors but no clinical candidates. This review diagnoses a systemic translational failure driven by single‐parameter optimisation and proposes a multiparametric framework integrating enzymatic potency, cathepsin selectivity, intracellular exposure, and metabolic ...
Caroline Rodrigues Chaves dos Reis, Hellen Valério Chaves Moura de Souza, Lidia Corrêa Parra, Guilber Valério Chaves Moura de Souza, Bruna Costa Zorzanelli, Nubia Boechat, Lucas Villas Bôas Hoelz, Tácio Vinício Amorim Fernandes   +7 more
wiley   +1 more source

Building Molecules by a Self-Replicator That Catalyzes Acyl Hydrazone Formation. [PDF]

Angew Chem Int Ed Engl
van Esterik KS, Marchetti T, Otto S.
europepmc   +1 more source

Pharmacology of estrogen-related receptors (ERRs) agonists. [PDF]

RSC Chem Biol
Radwan MO, Guin S, Burris TP.
europepmc   +1 more source

Discovery of SHANK1-PDZ Peptide-Fragment Inhibitors Using a Dynamic Ligation Screening Strategy. [PDF]

Biochemistry
Li Y, Gimenez D, Warriner SL, Wilson AJ.
europepmc   +1 more source

Polymeric Theranostics with Tetraphenylporphyrin for Effective Low-Dose Photodynamic Cancer Therapy. [PDF]

Pharmaceutics
Turnovská A, Gao S, Tavares MR, Hynek J, Lang K, Fang J, Etrych T.   +6 more
europepmc   +1 more source

Synthesis, SAR, and multi-target evaluation of isonicotinoyl hydrazones as potent MPO/AChE inhibitors and metal chelators for Alzheimer's disease. [PDF]

Sci Rep
Wei Z, Liu Z, Chang Y, Wang Z, Guo B, Ma X, Zhao K.   +6 more
europepmc   +1 more source