Results 171 to 180 of about 10,821 (234)

KAT6A–inhibitor co‐crystal structures: tackling a challenging crystallization target via two alternative approaches

Acta Crystallographica Section D, Volume 82, Issue 9, Page 1111-1124, September 2026.
We report a novel cysteine‐to‐serine surface‐mutation approach to determine co‐crystal structures of KAT6A with small‐molecule inhibitors and compare it with the previously published MYSTcryst approach which uses mutated KAT8 as a surrogate for KAT6A.
Vera Puetter, Léa Bouché, Katrin Nowak-Reppel, Steven J. Ferrara, Stefan N. Gradl, Daniel Korr, Craig A. Strathdee, Antonius ter Laak, Roman C. Hillig   +8 more
wiley   +1 more source

Apigenin Alleviates Pyroptosis in Lung Adenocarcinoma Cells by Modulating TNF‐α/NF‐κB Signaling and AIM2 Inflammasome Activation

Thoracic Cancer, Volume 17, Issue 17, September 2026.
Apigenin attenuated CCCP/FeSO4‐induced injury and pyroptosis‐associated molecular changes in A549 cells by suppressing TNF‐α/NF‐κB signaling and reducing AIM2/ASC‐associated protein expression. Integrated network pharmacology, molecular docking, molecular dynamics simulations, and LUAD transcriptomic analyses further prioritized TNF and AIM2 as ...
Kairui Zhu, Yulong Mu, Zhenguo Su, Zhen Yue, Dongyang Wu, Guiwu Qu, Chenyang Jiang, Qing Li, Youjie Li, Ning Xie   +9 more
wiley   +1 more source

Investigation of the In Vitro and In Silico Anticancer Potential of Novel 4‐Arylthiazole‐Hydrazone Derivatives

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
The synthesized compounds exhibited excellent cytotoxicity on MCF‐7, breast cancer cell line with selective profile especially 2d with IC50 value of 0.12 μM. Three compounds 2c, 2d, and 2h caused almost as much apoptosis induction as cisplatin. Compound 2d exhibited caspase‐3 activation at standard drug level.
Zeynep Zişan Demirci, Erol Akgün, Gülşen Akalın Çiftçi, Leyla Yurttaş   +3 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Anthracene Derivatives as Potent Antioxidants: Experimental, DFT, and Docking Studies

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
A series of anthracene‐based derivatives exhibited exceptional antioxidant activity, with IC50 values surpassing ascorbic acid. DFT and molecular docking studies revealed efficient charge transfer and strong Keap1/Nrf2 binding, highlighting their potential as promising therapeutic agents against oxidative stress.
Mohamed R. Elmorsy, Menna Moustafa, Hassan A. Etman, Nashwa M. El‐Metwaly, Safa A. Badawy   +4 more
wiley   +1 more source

Design, Synthesis, Antimycobacterial Evaluation, and In Silico Investigation of Benzisothiazole‐Based Hydrazide Derivatives as Potential Anti‐Tuberculosis Agents

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
A novel series of benzisothiazole‐based hydrazide derivatives was designed, synthesized, and evaluated for antitubercular activity. Compound 8k emerged as the most potent candidate (MIC = 0.25 μg/mL) with a high selectivity index (SI = 42) and bactericidal activity. Molecular docking and 100 ns simulations identified InhA as the probable target.
Vivek Sharma, Arun Sharma, Ruchi Poria, Pardeep Kumar   +3 more
wiley   +1 more source

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Hydrazones

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
S. Kim, J.‐Y. Yoon
openaire   +1 more source

Hole-transporting hydrazones

Chemical Society Reviews, 2008
This tutorial review covers recent contributions in the area of hole-transporting hydrazones, which are widely used in optoelectronic devices. It is addressed to students and researchers interested in the synthesis and properties of organic electroactive materials.
Ramūnas, Lygaitis, Vytautas, Getautis, Juozas Vidas, Grazulevicius   +2 more
openaire   +2 more sources

Analytical applications of hydrazones

Talanta, 1975
A review of the analytical applications of hydrazones is presented.
M, Katyal, Y, Dutt
openaire   +2 more sources

Hydrazones

Chemistry of Heterocyclic Compounds, 1974
Yu. P. Kitaev, T. V. Troepol'skaya, L. N. Orlova   +2 more
  +5 more sources

The Chemistry of Hydrazonates

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
null Ahmad Sami Shawali, null Sherif Mourad Sherif   +1 more
openaire   +1 more source