Results 161 to 170 of about 10,821 (234)

Exploiting the B–N/C–C Isosterism Yields Nile‐Red Inspired Organoboron Dyes Capable of Singlet‐Oxygen Photosensitization

ChemistryEurope, Volume 4, Issue 9, September 2026.
B─N bridged Nile Red derivatives: B─N/C─C isosterism enables a new class of Nile Red (NR) derivatives featuring a B─N linkage connecting both the western and eastern fragments of NR. The resulting NR‐inspired boronic acid‐derived salicylidenehydrazone (NR‐BASHY) complexes showcase promising photophysical properties, targeted bioimaging capability, and ...
João Felicidade, Francisco G. Blandón‐Cumbreras, Jesús F. Arteaga, Patricia Remón, Adelaide Fernandes, Giulia Salluce, Gilles Gasser, Francisco Nájera, Fábio M. F. Santos, Uwe Pischel, Pedro M. P. Gois   +10 more
wiley   +1 more source

Co‐Acid Free Nitration of N,N‐Dimethylanilines Using Traditional and Nontraditional Activation Methods

Chemistry–Methods, Volume 6, Issue 9, September 2026.
Selective mono‐ and dinitration of dimethylanilines by co‐acid‐free dilute aqueous nitric acid using nontraditional activation methods, such as microwave, ultrasound, and high hydrostatic pressure. The nitration of aromatic compounds is a highly important transformation, contributing to the synthesis of dyes, agrochemicals, explosives, pharmaceuticals,
Kelsey M. Plasse, Lyah K. Esplana, Béla Török   +2 more
wiley   +1 more source

Detection of Testosterone Esters in Urine: Evidence of Trace‐Level Detectability in Doping Control Samples

Drug Testing and Analysis, Volume 18, Issue 9, Page 1157-1162, September 2026.
An ultrasensitive LC‐MS/MS method for detecting testosterone esters (T‐esters) in urine at sub–pg/mL levels is presented. This approach, employing Girard P derivatization, provides the first evidence of T‐esters' trace‐level detectability in human urine.
Daniel Pecher, Guro Forsdahl, Biljana Stojanovic, Günter Gmeiner   +3 more
wiley   +1 more source

Flow Synthesis of Muscone‐Macrocycles Using the Eschenmoser Rearrangement as a Key Step

Helvetica Chimica Acta, Volume 109, Issue 9, September 2026.
A two‐step flow process, comprising the formation of hydrazones followed by Eschenmoser fragmentation, enables the efficient synthesis of macrocyclic ketones, which serve as precursors for exaltone and muscone. ABSTRACT Hydrazone formation followed by Eschenmoser fragmentation are key steps in the synthesis of muscone‐type macrocycles.
Merlin Hauer, Oliver Fifield, Florian Fricke, Alexandra Seeman, Ian R. Baxendale, Johannes Panten, Andreas Kirschning   +6 more
wiley   +1 more source

Fisetin Attenuates Amyloid‐Beta‐Induced Neurotoxicity in Human Neuroblastoma SH‐SY5Y Cells: Integrating In Silico Target Prediction and In Vitro Validation

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
The in‐silico data showed that fisetin binds stably with the autophagy receptors and synaptic density regulators. Further, in‐vitro data confirmed the restoration of Aβ1‐42 disrupted autophagy by fisetin. Fisetin restored the oxidative stress and ion channels, along with a reduction of AChE activity.
Charu Jaiswal, Ishika Singh, Abhishek Kumar Singh   +2 more
wiley   +1 more source

Quinoline and Phthalimide Substituted Silicon Phthalocyanines as Multi‐Target Inhibitors of Cholinesterases and Carbonic Anhydrases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Two novel axially substituted silicon phthalocyanines were synthesized and characterized. Compound 2a exhibited significantly enhanced inhibition of AChE, BChE, hCA I and hCA II, supported by molecular docking and SAR analysis, highlighting its potential as a multifunctional enzyme inhibitor with promising biological activity.
Seda Ünlü, Zeynep Köksal, Kevser Kübra Kırboğa, Fikriye Tuncel Elmalı   +3 more
wiley   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source

Emerging Chemical Upcycling and Repurposing Strategies for Waste Pharmaceuticals

ChemistrySelect, Volume 11, Issue 36, 22 September 2026.
What could be done with pharmaceutical waste from a circular chemistry perspective? A literature survey was conducted using the terms “recycling”, “upcycling”, “reuse”, “repurposing”, “pharmaceutical”, “expired drug”, “expired medicine”, “unused drug” and “unused medicine” in the databases Scopus, Web of Science and Periódicos CAPES to answer this ...
Letícia Ribeiro Magalhães, Lourena Mafra Veríssimo, Euzébio Guimarães Barbosa, Alessandro Kappel Jordão   +3 more
wiley   +1 more source

Cancer Vaccine Development: Toward Artificial Intelligence‐Assisted Personalized Cell Membrane Nanovaccine

Small, Volume 22, Issue 49, 1 September 2026.
Cancer nanovaccines have emerged as promising alternatives to conventional cancer vaccines, which have shown limited clinical efficacy. In particular, cell membrane nanoparticle‐based nanovaccines can offer high biocompatibility and immunogenicity while preserving tumor antigens, including antigen repertoires.
Munsik Kim, Ilkoo Noh
wiley   +1 more source

Volatile Organic Compounds in Rainwater: A New Frontier in Atmosphere–Biosphere Interactions

Journal of Geophysical Research: Biogeosciences, Volume 131, Issue 9, September 2026.
Abstract Rainwater is a key vector of atmospheric deposition, linking the atmosphere with terrestrial and aquatic ecosystems. While the inorganic chemistry of precipitation (dominated by sulfate, nitrate, ammonium, and trace metals) has been extensively studied, organic compounds in rainwater have received less attention, and Volatile Organic Compounds
Ana M. Yáñez‐Serrano, Teresa Moreno, Maria Izquierdo, Jorge Pey, Roger Seco, Andrés Alastuey, Josep Peñuelas   +6 more
wiley   +1 more source