Results 141 to 150 of about 31,731 (271)
Self‐Immolative Gels: Programmable Degradation Using Self‐Immolative Linkers and Polymers
Chemistry – A European Journal, Volume 32, Issue 23, 16 June 2026.Self‐immolative linkers and polymers undergo bond‐cleaving reaction cascades in response to specific stimuli. Their incorporation into gels can be harnessed to release cargo, induce property changes, or trigger degradation in a highly controlled manner. These functions can be employed in applications such as sensing and drug delivery.
Chuanfeng Li, Elizabeth R. Gillies
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.Die geminale Difunktionalisierung leicht verfügbarer Bausteine ermöglicht einen schnellen Zugang zu molekularer Komplexität. Diese Arbeit stellt eine Strategie vor, um zwei unterschiedliche funktionelle Gruppen an einem Carbonylkohlenstoff zu installieren, indem dieser in eine Donor–Donor‐Diazo‐Verbindung überführt wird. Die Methode ist sowohl im Batch‐
Vincent George +13 more
wiley +1 more source
Spectroscopy, Electrochemistry and Photochemistry of Phenylazonaphthalene Dyes [PDF]
, 2010 The spectroscopy, electrochemistry and photochemistry of seven 2-(4-R-phenylazo)naphthalene-4,8-disulfonate dyes (R-Span dyes), were studied to report on their structure and reactivity in water.
Bullivant, Chad Quentin
core
Angewandte Chemie International Edition, Volume 65, Issue 25, 15 June 2026.Geminal difunctionalization of readily available building blocks provides rapid access to molecular complexity. This work introduces a strategy for installing two distinct functional groups on a carbonyl carbon by transforming it into a donor–donor diazo compound, enabling both batch and flow applications with broad solvent compatibility.
Vincent George +13 more
wiley +1 more source
Bayesian Optimization of Solvent‐Free Thermal Amidation via Reactive Extrusion
Chemistry – A European Journal, Volume 32, Issue 22, 9 June 2026.Thermal amidation between a carboxylic acid and an amine was successfully conducted in an extruder in the absence of solvent, coupling agent, or catalyst, relying on an adapted Bayesian Optimization protocol. Active pharmaceutical ingredient moclobemide was synthesized on a larger scale, achieving excellent yield and low Process Mass Intensity (PMI ...
Matthieu Lavayssiere +2 more
wiley +1 more source
Advanced Synthesis &Catalysis, Volume 368, Issue 11, 3 June 2026.In this work, we successfully synthesized a library of novel N‐amidinyl‐benzodiazaborines, showing how these heteroaryl guanyl hydrazones are able to stabilize the retromer, a protein complex involved in the disposal of misfolded and aggregated proteins, whose malfunction is observed in multiple neurodegenerative diseases.
Alessandro Dimasi +10 more
wiley +1 more source
Azide‐to‐Diazo Transformation Facilitated by Michael Addition via Phosphazide Formation
Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.A new type of Michael addition based on azide‐to‐diazo conversion is disclosed. This unusual transformation proceeds via 1,4‐addition accompanied by N─N bond cleavage of phosphazide intermediates under practical conditions. The high versatility of the resulting Michael adducts enables the synthesis of a wide variety of organonitrogen compounds ...
Tomoki Mano +3 more
wiley +2 more sources
FEBS Letters, Volume 600, Issue 12, Page 1699-1716, June 2026.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Convergent Total Synthesis of 16β‐Hydroxylpseudobufarenogin
Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.We present a novel convergent strategy that integrates Pd/Ag‐promoted Suzuki–Miyaura coupling with Ir‐catalyzed radical‐relay cyclization, enabling the first total synthesis of 16β‐hydroxylpseudobufarenogin. This approach is broadly applicable to the total synthesis of various oxygenated bufadienolides by simply modifying the fragment structures ...
Wataru Shigematsu +3 more
wiley +2 more sources
Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers
Advanced Functional Materials, Volume 36, Issue 44, 1 June 2026.A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley +1 more source