Results 141 to 150 of about 10,821 (234)

Mitochondrial physiology in cardiac muscle of deer mice native to high altitude

The Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude deer mice exhibited evolved changes in mitochondrial energy metabolism and reactive oxygen species (ROS) management that may support cardiac performance under cold hypoxic conditions. High‐altitude mice had increased activity of lactate dehydrogenase (LDH) in the heart, probably enhancing the capacity for lactate ...
Ranim Saleem, Samuel G. Robichaud, Simon G. Lamarre, Graham R. Scott   +3 more
wiley   +1 more source

Design, Synthesis and Molecular Docking Studies of Some Novel Hydrazone Derivatives Based on Trimetazidine as Selective and Potent AChE Inhibitors

Drug Development Research, Volume 87, Issue 7, November 2026.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disease, and cholinergic dysfunction is considered one of the fundamental pathological factors of this disease. Guided by the clinically used acetylcholinesterase (AChE) inhibitor donepezil, we explored trimetazidine dihydrochloride as an accessible starting scaffold to generate ...
Muhammed Oğuzhan Doğan, Begüm Nurpelin Sağlık Özkan, Abdullah Burak Karaduman, Sevgi Karakuş, Yusuf Özkay, Zafer Asım Kaplancıklı, Fatih Tok   +6 more
wiley   +1 more source

Covalent Organic Frameworks in Smart Food Packaging: Advances, Challenges, and Future Prospects

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 6, November 2026.
ABSTRACT Food preservation challenges have positioned packaging as a rapidly evolving, innovation‐driven field, with smart packaging offering transformative solutions. Among advanced materials, covalent organic frameworks (COFs) have attracted growing attention due to their permanent porosity, structural tunability, high surface area, and chemical ...
Sara Esteghlal, Hossein Daneshgar, Navid Rabiee, Mohammadreza Khalesi   +3 more
wiley   +1 more source

Novel Pyrazole‐4‐Carbaldehyde Derivatives Having Potent COX‐2 Inhibition and Anti‐Tubercular Activity: Microwave‐Assisted Green Synthesis and Molecular Docking

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
ABSTRACT A series of 1‐(4‐Chorophenyl)‐3Aryl‐1‐H‐pyrazole‐4‐carbaldehyde derivatives were synthesized under the microwave irradiation (MW) technique. IR, 1H‐NMR, 13C‐NMR, and mass spectroscopic techniques were used to confirm the structure of the synthesized compounds.
Megha Kokane, Dnyandev Bhosale, Dattatraya Raut, Pushpa Hadimani, Ashwini Narale, Prafulla Choudhari, Anjana Lawand   +6 more
wiley   +1 more source

Transcending Lipophilicity: Design of Oxotriphenylhexanoate (OTHO) Hydrogels Decorated With 9,10‐Diphenylanthracene Fluorescent Probes via Late‐Stage Polarity Swap

ChemistryOpen, Volume 15, Issue 10, October 2026.
Transferring robust organogelator cores to water is a promising approach to extend the scope and simplify the preparation of functional hydrogels, of interest in biomedical applications. We demonstrated this strategy by obtaining 9,10‐diphenylanthracene‐decorated oxotriphenylhexanoate hydrogels through organic solvent–based chemistry followed by late ...
Michel Taheri, Mario Martos, Olivia Lundgren, Henrik Sundén   +3 more
wiley   +1 more source

Photodegradation of Azo and Hydrazone Colourants on Cellulose‐Based Materials: A Mass Spectrometric Screening

ChemistrySelect, Volume 11, Issue 37, 6 October 2026.
Natural‐light ageing of early azo dyes and hydrazone pigments (AY36, AO7, and AR1) on cellulose‐based supports produces marked chromatic changes and distinct molecular transformations. LC–HRMS analysis of aged AY36 reveals degradation products associated with N‐oxidation, N‐dearylation, azo‐bond oxidation, and formaldehyde addition, providing a first ...
Adele Ferretti, Tommaso Nacci, Ilaria Degano   +2 more
wiley   +1 more source

Thiazolidine‐2,4‐dione and Thiazole Derivatives as Privileged Structures for Dengue Virus: A Review of Medicinal Chemistry Aspects

ChemistrySelect, Volume 11, Issue 37, 6 October 2026.
This graphical abstract summarizes thiazole, thiazolidine‐2,4‐dione, and hybrid compounds investigated as antiviral candidates against dengue virus. Representative structures and reported potencies are presented in the context of DENV serotypes. Proposed molecular targets include NS2B–NS3 protease and NS5.
Pedro César de Souza, Thaynara Paula Warren Bezerra, Matheus Vinicius Guimarães de Melo, Thayná da Silva Barros, Matheus Italo da Conceição, Michelle Melgarejo da Rosa, Moacyr Jesus Barreto de Melo Rêgo   +6 more
wiley   +1 more source

Lichtgesteuerte Dosierung der PPARγ‐Aktivierung Mittels Schnell Relaxierender Photoschalter

Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.
Um eine räumlich‐zeitliche Kontrolle der PPARγ‐Aktivität zu ermöglichen, entwickelten wir den schnell relaxierenden photoschaltbaren Agonisten 6, der PPARγ selektiv in seinem lichtinduzierten Z‐Zustand aktiviert und innerhalb von Sekunden (t1/2 = 47 s) in den inaktiven E‐Zustand relaxiert.
Loris Knümann, Alba Rodriguez‐Paniagua, Martin Reynders, Silke Duensing‐Kropp, Oliver Thorn‐Seshold, Vasily Morozov, Julian A. Marschner, Daniel Merk   +7 more
wiley   +1 more source

Dosing PPARγ Activation With Light Using Fast Relaxing Photoswitches

Angewandte Chemie International Edition, Volume 65, Issue 40, 28 September 2026.
To achieve spatiotemporal control over PPARγ activity, we designed the fast‐relaxing photoswitchable agonist 6 that selectively activates PPARγ in its light‐induced Z‐state and relaxes within seconds (t1/2 47 s) to the inactive E‐state. This unique profile allowed light‐dosed receptor activation in in vitro settings, enabling biological studies on ...
Loris Knümann, Alba Rodriguez‐Paniagua, Martin Reynders, Silke Duensing‐Kropp, Oliver Thorn‐Seshold, Vasily Morozov, Julian A. Marschner, Daniel Merk   +7 more
wiley   +1 more source

A Blood–Brain Barrier‐Permeable Guanylhydrazone Analogue of the ASIC3 Activator GMQ Inhibits Human Glioblastoma Stem Cell Growth In Vitro

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
The acid‐sensing ion channel 3 (ASIC3), physiologically located in the peripheral nervous system, was found in stem cells of CNS‐located glioblastoma multiforme (GBM CSCs); its chronic activation in the CNS kills dysfunctional GBM CSCs with no effect on ASIC3‐lacking CNS tissues.
Leonardo Maiorana, Nicoletta Collura, Andrea Gotti, Giulia De Leonardis, Greta Donati, Alice Maiocchi, Luciana Marinelli, Andrea Menegon, Pierfausto Seneci   +8 more
wiley   +1 more source