Results 131 to 140 of about 10,821 (234)

Rheological and Mechanical Assessment of Injectable Hydrogels: A Framework for Structure–Property Analysis

Polymer Engineering &Science, EarlyView.
A rheological and mechanical assessment framework to construct structure‐property‐application relationships for injectable hydrogels. ABSTRACT Injectable hydrogels have attracted massive research attention thanks to their potential biomedical applications.
Hai Xin, D. S. Abdullah Al Maruf, Boyang Wan   +2 more
wiley   +1 more source

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

Journal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá, Ladislav Androvič, Marcela Filipová, Michal Pechar, Richard Laga   +4 more
wiley   +1 more source

Reconciling Granular Hydrogel Microstructure and Mechanics via a Temporary Thermo‐Responsive and Cell‐Invadable Matrix

Small, EarlyView.
Thermo‐responsive granular hydrogels (TRGHs), composed of microparticles and an interstitial matrix, exhibit thermo‐responsive mechanical properties and allow cell infiltration. This system effectively addresses the conventional compromise between mechanical strength and porosity observed in granular hydrogels.
Jun Kim, Soyeon Kwon, Taimoor H. Qazi
wiley   +1 more source

Covalent Organic Framework Electrolytes for Solid‐State Lithium Batteries: Designing Ion Highways for Next‐Generation Energy Storage

Small, EarlyView.
Covalent organic frameworks provide a structurally programmable platform for solid‐state lithium batteries. This review outlines a design framework linking structural descriptors to ion‐transport metrics. It examines mechanisms of confinement, channel architecture, and hybrid designs, addressing the reasons for the occasional failure of high intrinsic ...
Rajesh Dhanushkotti, Ningaraju G. N., Karthik C. S., Karthik V, Anil Kumar M R, Jitendrasingh Rajpurohit, Jeremy I. G. Dawkins, Karim Zaghib   +7 more
wiley   +1 more source

Pyrene‐linked heterocyclic pyrazoles: Synthesis, antimicrobial screening, and in silico molecular insights

Smart Molecules, EarlyView.
A series of novel pyrene‐linked heterocyclic pyrazoles were synthesized and structurally characterized. The compounds were evaluated for antimicrobial activity against selected bacterial and fungal strains, showing promising inhibitory effects. Molecular docking studies provided insights into binding interactions and structure–activity relationships ...
Dinkal V. Kasundra, Paresh N. Patel
wiley   +1 more source

Design, synthesis, molecular modeling, in vitro evaluation of novel piperidine-containing hydrazone derivatives as cholinesterase inhibitors

In an effort to develop new and effective therapeutic agents for Alzheimer's disease, a series of hydrazone derivatives bearing piperidine rings have been designed and synthesized.
Tatar Yılmaz, Gizem, Baltaş, Nimet, Kaya, Süleyman, Koçyiğit-Kaymakçıoğlu, Bedia, Tok, Fatih, Çevik, Özge, Abas, Burçin İrem   +6 more
core   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

Four‐dimensional immuno‐mechanobiomaterials: Dynamic material cues that program host response to prevent fibrosis and enable regeneration

VIEW, EarlyView.
Dynamic immuno‐mechanobiomaterials with time‐programmed mechanical adaptation orchestrate host responses through precise mechanotransduction and immune‐stromal regulation. These adaptive biomaterials minimize mechanical mismatch, attenuate the forign dy response and fibrosis, promote angiogenesis and controlled extracellular matrix remodeling, and ...
Gobinath Vellapalayam Manoharan, Kathirvel Ayyaswamy, Parthasarathy Vellaichamy, Nagarajan Deivanayagam Pillai, Rithik Gobinath   +4 more
wiley   +1 more source

Advances in organic UV filters for sunscreens over the past decade

Photochemistry and Photobiology, EarlyView.
Highlighted organic UV filter frameworks that have been described for sunscreens over the past decade divided into three groups: derivatives of or inspired by approved organic UV filters, natural product‐based compounds, and miscellaneous. Abstract Ultraviolet (UV) radiation is a major environmental factor in photoaging, erythema, and skin cancer ...
Gabriela Zanella Marcon, Maria Carolina Theisen, Andressa Motta Castro, Giovana Jones Radke, Fernando Fumagalli   +4 more
wiley   +1 more source

NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga, Matheus B. Rocha, Ana P. Morelli, Raul G. da Costa, Marcelo A. S. Mori, Adelino S. R. da Silva, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle   +8 more
wiley   +1 more source