Results 31 to 40 of about 576,528 (285)

Massive dolomitization driven by MgSO-rich seawater and its effects on thermochemical sulfate reduction, Upper Permian Changxing Formation, northeastern Sichuan, China

Energy Exploration & Exploitation, 2022
Massive dolostones replacing build-ups and containing H2S of thermochemical sulfate reduction (TSR) origin occur in the Upper Permian reef and bank deposits, northeastern Sichuan, China, despite the absence of gypsum or anhydrite deposits, which are ...
Kaikai Li, Chunfang Cai, Xianfeng Tan, Hua Jiang, Junjia Fan   +4 more
doaj   +1 more source

Laboratory Investigation of Hydraulic Fracture Behavior of Unconventional Reservoir Rocks

Geosciences, 2021
The heterogeneity of the rock fabric is a significant factor influencing the initiation and propagation of a hydraulic fracture (HF). This paper presents a laboratory study of HF created in six shale-like core samples provided by RITEK LLC collected from
Maria Bobrova, Sergey Stanchits, Anna Shevtsova, Egor Filev, Vladimir Stukachev, Tagir Shayahmetov   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

C(sp3)–heteroatom bond formation by iron-catalyzed soft couplings

Communications Chemistry
Carbon–heteroatom bonds are of great importance due to their prevalence in pharmaceuticals, agrochemicals, materials, and natural products. Despite the effective use of metal-catalyzed cross-coupling reactions between sp2-hybridized organohalides and ...
Julius Semenya, Yuanjie Yang, Hye Joon Lee, Kimberly A. Giannantonio, Rikhil Manduva, Elias Picazo   +5 more
doaj   +1 more source

Structure-Based Virtual Screening and De Novo Design of PIM1 Inhibitors with Anticancer Activity from Natural Products

Pharmaceuticals, 2021
Background: the proviral insertion site of Moloney murine leukemia (PIM) 1 kinase has served as a therapeutic target for various human cancers due to the enhancement of cell proliferation and the inhibition of apoptosis.
Hwangseo Park, Jinwon Jeon, Kewon Kim, Soyeon Choi, Sungwoo Hong   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Establishing Lagrangian connections between observations within air masses crossing the Atlantic during the International Consortium for Atmospheric Research on Transport and Transformation experiment [PDF]

, 2006
The ITCT-Lagrangian-2K4 (Intercontinental Transport and Chemical Transformation) experiment was conceived with an aim to quantify the effects of photochemistry and mixing on the transformation of air masses in the free troposphere away from emissions. To
A. C. Lewis, A. Stohl, B. Rappenglück, Bates, C. E. Reeves, D. D. Parrish, D. R. Blake, Day, Derwent, E. Atlas, Eckhardt, Esler, F. M. Flocke, Fehsenfeld, Fitzgerald, Forster, Frost, Guenther, H. B. Singh, H. Coe, H. Schlager, Haynes, Hoell, Huebert, J. Crosier, J. McQuaid, J. Methven, J. R. Hopkins, J. S. Holloway, Jobson, Johnson, K. Law, L. K. Whalley, Legras, Lehmann, Lewis, M. Avery, M. J. Evans, Methven, Methven, N. M. Watson, Olivier, P. I. Williams, P. S. Monks, Parrish, Parrish, Pfister, Prinn, R. Purvis, Raes, Real, Rex, Riddle, S. R. Arnold, Stohl, Stohl, Stohl, Stohl, Wood   +58 more
core   +4 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Reciprocal Sum Expression for Steady-state Kinetics —Enzyme Reactions and Voltammetry—

Electrochemistry, 2022
Steady-state experiments are often conducted to understand complicated cases in chemistry, since the kinetics does not have a time valuable and allows simple modeling of the reactions.
Yuko YOKOYAMA, Masahiro YAMAMOTO, Kohei MIYAZAKI, Takeshi ABE, Kenji KANO   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source