Results 31 to 40 of about 746,382 (358)
Pharmaceuticals, 2021 Background: the proviral insertion site of Moloney murine leukemia (PIM) 1 kinase has served as a therapeutic target for various human cancers due to the enhancement of cell proliferation and the inhibition of apoptosis.
Hwangseo Park +4 more
doaj +1 more source
Characterization of the transverse relaxation rates in lipid bilayers [PDF]
, 1990 The 2H NMR transverse relaxation rates of a deuterated phospholipid bilayer reflect slow motions in the bilayer membrane. A study of dimyristoyl lecithin specifically deuterated at several positions of the hydrocarbon chains indicates that these motions ...
Chan, Sunney I. +2 more
core
Future of oil and gas development in the western Amazon [PDF]
, 2014 The western Amazon is one of the world's last high-biodiversity wilderness areas, characterized by extraordinary species richness and large tracts of roadless humid tropical forest.
Babbitt, Bruce +7 more
core +2 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
C(sp3)–heteroatom bond formation by iron-catalyzed soft couplings
Communications ChemistryCarbon–heteroatom bonds are of great importance due to their prevalence in pharmaceuticals, agrochemicals, materials, and natural products. Despite the effective use of metal-catalyzed cross-coupling reactions between sp2-hybridized organohalides and ...
Julius Semenya +5 more
doaj +1 more source
ElectrochemistryA H15P3V6Mo18O84 aqueous solution containing phosphovanadomolybdate anions such as [PV3Mo9O40]6− and [PV2Mo10O40]5− were applied to a catholyte of redox flow polymer electrolyte fuel cells (PEFCs).
Shinji NARUSE +5 more
doaj +1 more source
Influence of Hydrate-Forming Gas Pressure on Equilibrium Pore Water Content in Soils
Energies, 2021 Natural gas hydrates (primarily methane hydrates) are considered to be an important and promising unconventional source of hydrocarbons. Most natural gas hydrate accumulations exist in pore space and are associated with reservoir rocks.
Daria Sergeeva +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Energy Exploration & Exploitation, 2022 Massive dolostones replacing build-ups and containing H2S of thermochemical sulfate reduction (TSR) origin occur in the Upper Permian reef and bank deposits, northeastern Sichuan, China, despite the absence of gypsum or anhydrite deposits, which are ...
Kaikai Li +4 more
doaj +1 more source