Results 241 to 250 of about 495,919 (291)

Integrative Profiling for BBB Permeability Using Capillary Electrochromatography, Experimental Physicochemical Parameters, and Ensemble Machine Learning. [PDF]

Int J Mol Sci
Godyń J, Jończyk J, Więckowska A, Bajda M.   +3 more
europepmc   +1 more source

Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

Advanced Science, EarlyView.
In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman, Gurcharan Kaur, Serra Kaya, Joanna Bons, Carlos Galicia Aguirre, Qi Liu, Christina D. King, Kenneth A. Wilson, Harrison L. Baker, Mikayla Hady, Nadja Maldonado Luna, Gregor Bieri, Saul A. Villeda, Lisa M. Ellerby, Birgit Schilling, Tamara Alliston   +15 more
wiley   +1 more source

Comorbidities and Concomitant Medications in Middle-Aged Japanese People According to the Charlson Comorbidity Index and Age: Results of the NDB-K7Ps-Study-3. [PDF]

Epidemiologia (Basel)
Sekine A, Nakajima K.
europepmc   +1 more source

Immobilization of Polar and Brown bears using Etorphine and Xylazine [PDF]

, 1982
Gatesman, T., Wiesner, Henning
core  

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Safe by Design Flow Technology for Diazoacetonitrile Generation and Direct Conversion to Pyrazoles. [PDF]

ChemistryOpen
Bošković D, Loebbecke S, Piscopo CG, Radulescu LJ, Schwarzer M.   +4 more
europepmc   +1 more source

PEC‐DFM Hybrid‐Sensor Based on Nanoparticle‐Resolved Estimation for Sensitive and Reversible Glucose Monitoring

Advanced Science, EarlyView.
Abstract The accurate detection of glucose in wound exudate is critically important for monitoring chronic wound healing. While photoelectrochemical (PEC) sensors are widely used, they often suffer from material degradation caused by redox reactions during operation. Herein, we introduce a dark‐field microscopy (DFM) setup integrated with a PEC system,
Zihao Zhang, Junzheng Liu, Qinggong Wu, Yuan Zeng, Gang Xiao, Zhao Yue, Zhigang Zang, Shuang Zhao   +7 more
wiley   +1 more source

Prospective, Single-Arm, Investigator-Initiated Study to Evaluate Efficacy and Safety of Levocetirizine Hydrochloride 5 mg and Montelukast 10 mg (L-Montus) in Patients With Seasonal Allergic Rhinitis and Perennial Allergic Rhinitis. [PDF]

Cureus
Ramappa C, Gola MK, Padmanabhan K, Jayaraman GV, Karuppan A, Shabbir A, S H.   +6 more
europepmc   +1 more source

Metal-Free Synthesis of 1,3-Divinylimidazolidin-2-One. [PDF]

ChemistryOpen
Lorenzen S, Graf R, Ignat'ev NV, Schulte M, Delp A, Calo F, Finze M.   +6 more
europepmc   +1 more source

Endovascular treatment for symptomatic vasospasm following traumatic brain injury: illustrative case. [PDF]

J Neurosurg Case Lessons
Kubota R, Nakano S, Kubota M, Tajima Y, Aoyagi K, Horiguchi K, Higuchi Y.   +6 more
europepmc   +1 more source