Results 311 to 320 of about 677,906 (386)

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

Prophylactic use of a combination of palonosetron hydrochloride and dexamethasone to prevent transcatheter arterial chemoembolization-induced nausea and vomiting among patients with hepatocellular carcinoma. [PDF]

Front Med (Lausanne)
Zhang WM, Zheng MJ, Li C, Chen LL, Yu C, Zhou JF, Zheng J.   +6 more
europepmc   +1 more source

Resolvin D5 Inhibits CXCL8 Expression in Colonic Epithelial Cells Through Activating GPR101 to Impede Neutrophil Recruitment and Consequently Alleviate Ulcerative Colitis

Advanced Science, EarlyView.
RvD5 effectively alleviates UC by inhibiting STAT1 signaling to reduce CXCL8 expression in colonic epithelial cells via activation of GPR101, which subsequently decreases the infiltration of neutrophils in the colonic mucosal epithelium. Epimedin A1, a natural allosteric inhibitor of 5‐LOX, demonstrates potential as a therapeutic agent for UC by ...
Pengxiang Guo, Yilei Guo, Yanrong Zhu, Ke Yan, Yulai Fang, Jiafeng Zhang, Yue He, Zhifeng Wei, Yufeng Xia, Yue Dai   +9 more
wiley   +1 more source

Preparation of colon-targeted pellets loaded with filgotinib/berberine hydrochloride and Their application in ulcerative colitis therapy. [PDF]

Int J Pharm X
Wang J, Kuang Z, Chen B, Yan C, Shi B, Li G.   +5 more
europepmc   +1 more source

A Recyclable Biochar with Ultrahigh Absorption Ability for Efficient Removal Of Tetracycline Hydrochloride

junling Duan, Rongrong Han, Yanguang Song, Shiyun Ai   +3 more
openalex   +1 more source

Disproportionality analysis of taste disorders using the FDA adverse event reporting system and Japanese adverse drug event report databases. [PDF]

Front Pharmacol
Kyotani Y, Nakahira K, Yoshizumi M.
europepmc   +1 more source

A clinical study on the effect of dry mouth for patients with Sjögren's syndrome - Administration was changed from Cevimeline hydrochloride hydrate to pilocarpine hydrochloride

, 2009
Hiroshi Mese, Akiyoshi Nishiyama, Akira Sasaki   +2 more
openalex   +1 more source

Patient Reported Experiences and Comfort Associated with Intravitreal Injection Technique: A Cross-Sectional Survey Approach. [PDF]

J Vitreoretin Dis
Afkhamnejad ER, Abdullah ZA, Nguyen OMQ, Shah AR, Rahman EZ, Wong TP, Chen E, Wykoff CC, Benz MS, Pearce WA, Nguyen VT, Brown DM, Kim RY, Fan KC, Henry CR, Fish RH, Patel SB.   +16 more
europepmc   +1 more source

CLINICAL OUTCOMES OF AMBROXOL HYDROCHLORIDE IN INFANTS WITH SECRETORY OTITIS MEDIA

chen liwen, Minghao, Jun Zhang, MD
openalex   +1 more source

Mitoxantrone hydrochloride liposome-based chemotherapy plus rituximab in elderly patients older than 80 years with diffuse large B-cell lymphoma: case report and review of the literature. [PDF]

Front Med (Lausanne)
Pi JP, Liu Y, Jin J, Zhang W, He XH.
europepmc   +1 more source