Results 41 to 50 of about 677,906 (386)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Novel N-phenyl-2-(aniline) benzamide hydrochloride salt development for colon cancer therapy

Frontiers in Pharmacology
IntroductionN-phenyl-2-(aniline) analog N53 is a previously discovered dual inhibitor of Topo I and COX-2, which exhibited significant anti-colon cancer activity in vitro, but the poor solubility and moderate anti-cancer activity in vivo hindered its ...
Yan Peng, Ying Peng, Wei Zhang, Siyi Zhang, Huiqian Peng, Zhen Li, Bo Li, Bo Li, Linyi Liu, Linsheng Zhuo, Zhen Wang, Zhen Wang, Zhen Wang, Zhen Wang, Junbo Wu, Weifan Jiang   +15 more
doaj   +1 more source

Electrostatically gated membrane permeability in inorganic protocells [PDF]

, 2013
Although several strategies are now available to produce functional microcompartments analogous to primitive cell-like structures, little progress has been made in generating protocell constructs with self-controlled membrane permeability.
A Boker, A Dzieciol, A Pohorille, AB Subramaniam, AB Subramaniam, AD Dinsmore, B Städler, Bernard P. Binks, C Wu, D Lee, DS Williams, DY Wang, GJT Cooper, J-W Kim, Jonathan V. M. Weaver, JVM Weaver, JW Szostak, KL Thompson, M Li, Mei Li, MF Hsu, P Stano, P Stano, P Walde, Rachel L. Harbron, RK Shah, RL Harbron, S Koga, S Mann, Stephen Mann, W Martin   +30 more
core   +4 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Acute Psychotic Symptoms due to Benzydamine Hydrochloride Abuse with Alcohol

Case Reports in Psychiatry, 2014
Benzydamine hydrochloride is a locally acting nonsteroidal anti-inflammatory drug. Benzydamine hydrochloride overdose can cause stimulation of central nervous system, hallucinations, and psychosis.
Yahya Ayhan Acar, Mustafa Kalkan, Rıdvan Çetin, Erdem Çevik, Orhan Çınar   +4 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Berberine hydrochloride inhibits cell proliferation and promotes apoptosis of non-small cell lung cancer via the suppression of the MMP2 and Bcl-2/Bax signaling pathways.

Oncology Letters, 2018
Berberine, also known as berberine hydrochloride and isoquinoline alkaloid, is a major alkaloid from Coptis chinensis. Berberine's extensive biological properties have previously been studied, and it has been used clinically for the treatment of diarrhea,
jie li, Fang Liu, Shulong Jiang, Jie Liu, Xiuhong Chen, Shangnuan Zhang, Haibo Zhao   +6 more
semanticscholar   +1 more source

Synthesis and Characterization of Lipid Coated Nanoparticles as Drug Delivery Vehicles [PDF]

, 2017
Spherical monodisperse nanoparticles composed of gold or silver cores were modified with lipids as part of an ongoing project to utilize functionalized nanoparticles as drug delivery vehicles.
Gilbert, Brian D., Munjar, Christopher W.   +1 more
core   +1 more source

Cyclopropanation of carbon-carbon double bonds in ring d of ergot alkaloids [PDF]

, 2013
Some ergot alkaloid derivatives containing a double bond in ring D have been reacted with diazomethane/palladium diacetate reagent to result in formation of a fused cyclopropane ring.
Dörnyei, Gábor, Hajós, György, Incze, Mária, Kovács, Péter, Lejtoviczné Egyed, Orsolya, Szántay, Csaba (Id.)   +5 more
core   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source