Results 41 to 50 of about 495,919 (291)

Synthesis and Characterization of Lipid Coated Nanoparticles as Drug Delivery Vehicles [PDF]

, 2017
Spherical monodisperse nanoparticles composed of gold or silver cores were modified with lipids as part of an ongoing project to utilize functionalized nanoparticles as drug delivery vehicles.
Gilbert, Brian D., Munjar, Christopher W.   +1 more
core   +1 more source

An observational study of Donor Ex Vivo Lung Perfusion in UK lung transplantation: DEVELOP-UK [PDF]

, 2016
Background: Many patients awaiting lung transplantation die before a donor organ becomes available. Ex vivo lung perfusion (EVLP) allows initially unusable donor lungs to be assessed and reconditioned for clinical use.
Andreasson, Andreasson, Anyanwu, Arcasoy, Avlonitis, Avlonitis, Behrendt, Benden, Bjørk, Boffini, Boffini, Botha, Brazier, Briggs, Brown, Bury, Charmaz, Christie, Couraud, Curtis, Cypel, Cypel, Cypel, Cypel, Cypel, Cypel, De Perrot, Department of Health, Entwistle, Fielding, Fischer, Fisher, Fisher, Fisher, Fisher, Fisher, Fisher, Gibbs, Glaser, Great Britain, Haugh, Henriksen, Information Services Division, Ingemansson, International Society for Heart and Lung Transplantation, ISD Scotland, Itano, Jirsch, Joint Formulary Committee, Kaba, Kaneda, Kierans, Korovesi, Krutsinger, Lee, Littlefield, Long, Lowton, Lowton, Machuca, Martins, Mays, Moran, Naef, National Health Service, National Heart Lung and Blood Institute, National Institute for Health and Care Excellence, National Institute for Health Care Excellence, NHS Blood and Transplant, NHS Blood and Transplant, NHS Business Service Authority, Office for National Statistics, Okada, OPTUM, Orens, O’Grady, RAND Health, RAND Health Corporation, Renshaw, Roberts, Royal College of Surgeons, Sage, Sanchez, Sanchez, Schaeffer, Siebert, Steen, Steen, Taylor, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Tikkanen, TransMedics, TransMedics, UK Government Department of Constitutional Affairs, van Enckevort, Wallinder, Ware, Warnecke, Warnecke, Wierup, World Medical Organization, XVIVO Perfusion, Zych   +102 more
core   +4 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Trends in long-term prescribing of dependence forming medicines [PDF]

, 2019
Using patient-level primary care data to estimate the extent to which antidepressant medicines are prescribed to people continuously for long periods of time.
McManus, S., Nguyen, A., Sehmi, R., Smith, N.   +3 more
core  

Comparative study of osteogenic activity of multilayers made of synthetic and biogenic polyelectrolytes [PDF]

, 2017
Polyelectrolyte multilayer (PEM) coatings on biomaterials are applied to tailor adhesion, growth, and function of cells on biomedical implants. Here, biogenic and synthetic polyelectrolytes (PEL) are used for layer-by-layer assembly to study the ...
Gonzalez-Garcia, Cristina, Groth, Thomas, Guduru, Deepak, Niepel, Marcus S., Salmeron-Sanchez, Manuel   +4 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Penetapan Kadar Triprolidina Hidroklorida Dan Pseudoefedrina Hidroklorida Dalam Tablet Anti Influenza Secara Spektrofotometri Derivatif [PDF]

, 2006
The determination of triprolidine hydrochloride and pseudoephedrine hydrochloride in anti influenza tablet has been performed using derivative spectrophotometry method.
Harianto, H. (Harianto), Hayun, H. (Hayun), Yenti, Y. (Yenti)   +2 more
core  

Towards Understanding the Structure, Dynamics and Bio-activity of Diabetic Drug Metformin

, 2018
Small molecules are often found to exhibit extraordinarily diverse biological activities. Metformin is one of them. It is widely used as anti-diabetic drug for type-two diabetes.
Bagchi, Biman, Bhattacharyya, Aninda J, Mondal, Sayantan, Mukherjee, Saumyak, Samajdar, Rudra N   +4 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Methionine 129 variant of human prion protein oligomerizes more rapidly than the valine 129 variant - Implications for disease susceptibility to Creutzfeldt-Jakob disease [PDF]

, 2004
The human PrP gene (PRNP) has two common alleles that encode either methionine or valine at codon 129. This polymorphism modulates disease susceptibility and phenotype of human transmissible spongiform encyphalopathies, but the molecular mechanism by ...
Abdessamad Tahiri-Alaoui, Andrew C. Gill, Petra Disterer, William James, Prusiner, Weissmann, Will, Bruce, Hill, Prusiner, Prusiner, Collinge, Windl, Palmer, Brown, Baker, Cervenakova, Parchi, Hill, Collinge, Hauw, Goldfarb, Goldfarb, Dlouhy, Dermaut, Croes, Liemann, Riek, Alonso, Baskakov, Jackson, Baskakov, Gill, Lu, Lu, Landon, Safar, Bessen, Zahn, Riek, Nguyen, Tahiri-Alaoui, Santini, Wong, Wildegger, Matouschek, Vendruscolo, Kim, Fasman, Baskakov, Qin, Oesch, Conway, Sayer, Rhie, Schatzl, Mead   +56 more
core   +1 more source