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Biotechnological transformation of hydrocortisone to 16α-hydroxy hydrocortisone by Streptomyces roseochromogenes

Applied Microbiology and Biotechnology, 2013
Streptomyces roseochromogenes is able to hydroxylate steroid compounds in different positions of their cycloalkane rings thanks to a cytochrome P-450 multi-enzyme complex. In this paper, the hydroxylation of the hydrocortisone in the 16α position, performed by bacterial whole cells, was investigated in both shake flask and fermentation conditions; the ...
Odile Francesca Restaino   +8 more
openaire   +5 more sources

Enzyme inhibition in human skin homogenates by hydrocortisone, hydrocortisone acetate and hydrocortisone butyrate

Archives for Dermatological Research, 1976
In fresh human skin homogenates, the activities of four enzymes, lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G-6-PDH), "acid" phosphatase (AcP), and "leucine aminopeptidase" (LAP) were assayed following an incubation with hydrocortisone, hydrocotisone acetate, or hydrocortisone-17-butyrate, respectively.
Bernard M. Gmeiner, Wolfgang P. Raab
openaire   +3 more sources

Chlorocoulometric determination of hydrocortisone and hydrocortisone acetate.

Farmaco (Societa chimica italiana : 1989), 1991
A chlorocoulometric method for the determination of small amounts of hydrocortisone and hydrocortisone acetate is presented. The method is simple and rapid, the results obtained are accurate and reproducible. It can be successfully applied to the determination of hydrocortisone and hydrocortisone acetate in pharmaceutical formulations.
Nikolić, Kosta   +3 more
openaire   +2 more sources

Hydrocortisone in Sepsis

2021
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis may worsen in septic shock, which is characterized by underlying circulatory, cellular, and metabolic abnormalities, associated with an increased risk of mortality [1].
Federico Longhini   +2 more
openaire   +2 more sources

Hydrocortisone

2017
Hydrocortisone is a synthetic preparation of the steroid hormone cortisol. Hydrocortisone is usually absorbed very quickly from the gut with generally 95% of the dose absorbed. Cortisol measured in the blood following ingestion reaches a peak after 1–2 hours and lasts in the blood for approximately 6 hours. The half-life of cortisol (hydrocortisone) is
Peter C. Hindmarsh, Kathy Geertsma
openaire   +2 more sources

Anaphylaxis and Hydrocortisone

Annals of Internal Medicine, 1988
Excerpt To the editor: We wish to report a case of anaphylaxis produced by intravenous administration of hydrocortisone sodium phosphate.
H al Mahdy, M Hall
openaire   +2 more sources

Determination of Hydrocortisone and Hydrocortisone Acetate in Antibiotic Mastitis Preparation

Journal of Pharmaceutical Sciences, 1966
A modified column partition chromatographic method has been developed for the determination of hydrocortisone and hydrocortisone acetate in antibiotic mastitis preparations. A sodium bicarbonate trap under a methyl alcohol-water stationary phase in Celite is used with two mobile phases.
Alfred Bracey   +2 more
openaire   +2 more sources

Hydrocortisone for adrenal insufficiency

Archives of disease in childhood - Education & practice edition, 2015
Thomas Addison first described Addison's disease in 1855 in patients who had adrenal tuberculosis, highlighting the importance of the adrenal cortex to survive. In 1952, a decade after the medical landmark discovery of cortisone as a treatment for inflammatory conditions, the first case of adrenal crisis and death in a patient on glucocorticoid therapy
Paul J Dimitri, Charlotte Elder
openaire   +3 more sources

Hydrocortisone‐Induced Convulsions

Journal of Toxicology: Clinical Toxicology, 2003
Glucocorticoids may indirectly cause convulsions by the induction of electrolytes abnormalities, severe hypertension, or severe hyperglycemia. These agents may rarely cause convulsions by a direct toxicity to the central nervous system (CNS). We describe a 23-yr-old patient with Crohn's disease in whom generalized convulsions developed on two occasions
Edy Stermer, Majed Odeh, Alexandra Lavy
openaire   +3 more sources

Hydrocortisone

BMJ, 1955
B. Russell, N. A. Thorne
  +4 more sources

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