Results 221 to 230 of about 218,816 (278)

Self-oscillating synchronematic colloids. [PDF]

Nat Commun
Leyva SG, Zhang Z, Olvera de la Cruz M, Bishop KJM.   +3 more
europepmc   +1 more source

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

Advanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li, Bolin Li, Yanan Hao, Bo Pang, Pan Li, Chunli Li, Yu Tang   +6 more
wiley   +1 more source

Influence of Novel "Umbrella"-Type Ladle Shroud on Liquid Steel Flow in a Two-Strand Slab Tundish: Physical and Numerical Modelling. [PDF]

Materials (Basel)
Cwudziński A, Fogaraš L, Demeter J, Demeter P, Buľko B.   +4 more
europepmc   +1 more source

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

Biomarker-targeted functionalized magnetic nanoparticles: synthesis and aptamer conjugation optimization toward Alzheimer's disease biosensing. [PDF]

Nanoscale Adv
Makridis A, Kazeli K, Katsipis G, Tzekaki EE, Pantazaki AA, Bosch C, Simon-Carbajo R, Angelakeris M.   +7 more
europepmc   +1 more source

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

Reinforcement Learning-Enabled Control and Design of Rigid-Link Robotic Fish: A Comprehensive Review. [PDF]

Sensors (Basel)
Dinh N, Vosbein D, Wang Y, Cui Q.
europepmc   +1 more source

Research on the reliability of the overall structure of submerged radial steel gate. [PDF]

PLoS One
Yu Y, Zhao Z, Zhang Z, Chen W, Zhong Y, An Y.   +5 more
europepmc   +1 more source