Results 231 to 240 of about 62,524 (309)

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Optimizing the heating performance of Trombe walls with ribbed surfaces using three-dimensional CFD analysis. [PDF]

Sci Rep
Salhi JE, Zarrouk T, Jain S, Barboucha M, Siddiqui MIH, Parvez S, Moreda GA.   +6 more
europepmc   +1 more source

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source

Enhancing performance of gravitational water vortex turbines through airfoil design and basin parameters. [PDF]

Sci Rep
Michel M, Alaktaa AH, Elsherbiny K, Mehanna A, Shehata AS.   +4 more
europepmc   +1 more source

Mass‐Transport–Engineered CCM Architecture Employing MPL‐Free Carbon Paper and Graphene‐Coated Ni Foam Channels for High‐Temperature PEM Fuel Cells

Advanced Science, EarlyView.
A CCM‐based architectural strategy is introduced for high‐temperature PEM fuel cells, enabling MPL‐free carbon paper gas diffusion layers via decal‐transfer processing. By co‐engineering the CCM, GDL, and a G‐foam flow field, oxygen transport is enhanced while phosphoric‐acid leakage is suppressed, resulting in high power density and stable operation ...
Seongmin Cho, Songi Oh, Mingyu Kim, Jung Hwa Choi, Sunjae Hwang, Ji‐Hoon Jang, Segeun Jang   +6 more
wiley   +1 more source

Hybrid methods in flood inundation modeling: a systematic review. [PDF]

Nat Hazards (Dordr)
Perera MDD, Angeloudis A, Siripatana A, Beevers L.   +3 more
europepmc   +1 more source

A Dual‐Functional Biohybrid Nanorobot to Synergistically Eradicate Biofilm and Degrade Antibiotic Resistance Genes

Advanced Science, EarlyView.
A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang, Tong Dou, Luokai Wang, Jingxian Yang, Wenrui Wang, Shuaitian Guo, Xiangyu Li, Xuefang Huang, Yunlei Xianyu, Dongsheng Wang   +9 more
wiley   +1 more source

Rainfall and Temporal Influences on the Hydrodynamics of a Vertical Subsurface Flow Constructed Wetland Treating Domestic Sewage. [PDF]

Water Environ Res
Silva G, da Silva Júnior ÉD.
europepmc   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Aquaticity as a Latent Dimension of Aquatic Performance: Conceptual Framework and Application to Breath-Hold Diving. [PDF]

J Funct Morphol Kinesiol
Drviš I, Vrdoljak D, Foretić N, Dujić Ž.   +3 more
europepmc   +1 more source