Results 91 to 100 of about 228,464 (284)

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

Responsive Acrylamide-Based Hydrogels: Advances in Interpenetrating Polymer Structures

Gels
Hydrogels, composed of hydrophilic homopolymer or copolymer networks, have structures similar to natural living tissues, making them ideal for applications in drug delivery, tissue engineering, and biosensors.
Lenka Hanyková, Julie Šťastná, Ivan Krakovský   +2 more
doaj   +1 more source

Microporous Microgel Assemblies Facilitating the Recruitment and Osteogenic Differentiation of Progenitor Cells for Bone Regeneration

Advanced Functional Materials, EarlyView.
There is a significant need for biomaterials with well‐defined stability and bioactivity to support tissue regeneration. In this study, we developed a tunable microgel platform that enables the decoupling of stiffness from porosity, thereby promoting bone regeneration.
Silvia Pravato, Haishuo Guan, Bianca M. Carrara, Mira Jacobs, Matteo Monticelli, Lukas Moser, Thomas Moragues, Andrew J. deMello, Tomaso Zambelli, Martin Ehrbar   +9 more
wiley   +1 more source

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Influence of polymerisation conditions on the properties of polymer/clay nanocomposite hydrogels [PDF]

, 2013
Free-radical polymerisation of acrylamide derivatives in the presence of exfoliated clay platelets has recently emerged as a new technique for the synthesis of strong and tough nanocomposite hydrogels (NCHs) with a unique hybrid organic/inorganic network
Abdurrahmanoglu, Anseth, Bera, Calvet, Carlsson, Dokter, Feng, Fengge Gao, Gao, Gao, Giraldo, Giz, Gong, Gu, Haraguchi, Haraguchi, Haraguchi, Haraguchi, Haraguchi, Hu, Ito, Kabiri, Kalfus, Kulicke, Liu, Martin Bencsik, Okay, Rinat Nigmatullin, Sakai, Schexnailder, Solomon, Solomon, Tamagawa, Tanaka, Wang, Wu, Xu   +36 more
core   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Effect of crosslinker length on the elastic and compression modulus of poly(acrylamide) nanocomposite hydrogels [PDF]

, 2017
Polymer hydrogelshave shown to exhibit improved properties upon the addition of nanoparticles; however, the mechanical underpinnings behind these enhancements have not been fully elucidated.
Asuri, Prashanth, Chang, A., Zaragoza, Josergio   +2 more
core   +1 more source

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

Surface Morphology at the Microscopic Scale, Swelling/Deswelling, and the Magnetic Properties of PNIPAM/CMC and PNIPAM/CMC/Fe3O4 Hydrogels

Gels, 2016
Poly(N-isopropylacrylamide) (PNIPAM) hydrogels containing carboxymethylcellulose (CMC) and CMC/Fe3O4 nanoparticles were prepared. Free-radical polymerization with BIS as cross-linker was used to synthesize the hydrogels. The morphology at the microscopic
Marianna Uva, Andrea Atrei
doaj   +1 more source

Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels

Materials Today Bio, 2020
Nanoliposomes are widely used as delivery vehicles for active compounds. Nanoliposomes from rapeseed phospholipids were incorporated into interpenetrating polymer network hydrogels of gelatin methacryloyl and alginate.
R. Kadri, J. Bacharouch, K. Elkhoury, G. Ben Messaoud, C. Kahn, S. Desobry, M. Linder, A. Tamayol, G. Francius, J.F. Mano, L. Sánchez-González, E. Arab-Tehrany   +11 more
doaj   +1 more source