Results 151 to 160 of about 149,736 (314)

Rational Design of Self-Healing Hydrogel with High Mechanical Strength and Self-Healing Efficiency: A Short Review

open access: yesGels
Self-healing hydrogels, a novel class of “smart” hydrogels, possess the ability to autonomously restore their network structure and mechanical properties following damage through the reconnection of a fractured three-dimensional network via reversible ...
Xiaogang Yu   +3 more
doaj   +1 more source

Aqueous Two‐Phase Bioinks for Discrete Packing and Compartmentalization of 3D Bioprinted Cells

open access: yesAdvanced Healthcare Materials, EarlyView.
Aqueous two‐phase systems (ATPS) enable the formation of biomimetic interfaces crucial for tissue engineering. However, clinical translation remains limited by the challenge of precisely controlling cellular compartmentalization. Here, we developed ATPS biomaterial inks for 3D bioprinting allowing tuneable droplet formation via NaCl modulation.
Martina Marcotulli   +17 more
wiley   +1 more source

Synthesis and characterization of novel pH sensitive PAAM-PMAA-CMC hydrogels and their applications in the controlled release of fertilizer

open access: yes, 2012
Recently, the applications of hydrogels as a carrier vehicle for the controlled release of fertilizers in the agricultural field have been extensively proposed due to the unique properties of these materials, such as their biodegradability, low-toxicity,
Bortolin, Adriel   +4 more
core  

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

open access: yesAdvanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin   +18 more
wiley   +1 more source

Temperature responsive hydrogels and nanoparticles for advanced drug delivery

open access: yes, 2014
textMany important therapeutic agents are associated with significant undesired side effects which often limit treatment duration and dosing. Specifically, most major classes of antitumor chemotherapeutics have deleterious effects on cell division and ...
Slaughter, Brandon Vaughn
core  

Genipin‐Crosslinked, Silane‐Anchored 3D Tumor–Stroma Microtissues for High‐Content On‐Chip Drug Testing

open access: yesAdvanced Healthcare Materials, EarlyView.
We describe a microfluidic tumor‐stroma co‐culture model, engineered to resist collagen‐hydrogel contraction driven by fibroblast activity. Surface silanization with APTES covalently anchors the matrix to the chip, while Genipin crosslinking progressively increases stiffness and elasticity without harming cells. This supports >10 days of co‐culture and
Doriane Le Manach   +4 more
wiley   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

open access: yesAdvanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami   +4 more
wiley   +1 more source

Preparation and characterization of hydrophobically modified polyacrylamide hydrogels by grafting glycidyl methacrylate

open access: yes, 2007
A modified polyacrylamide (PAM-g-GMA) has been prepared by ring-opening reaction of glycidyl methacrylate (GMA) monomer grafted onto the -COO - groups of partially hydrolytic polyacrylamide (PAM) chain. The modified polyacrylamide hydrogels were obtained
Song, Pingan   +2 more
core   +1 more source

Functional Precision Oncology Approach Using Nanoliter Droplet Array for Drug Sensitivity Testing in Lung Cancer

open access: yesAdvanced Healthcare Materials, EarlyView.
A miniaturized drug sensitivity and resistance testing (DSRT) workflow based on the Droplet Microarray (DMA) platform enables functional drug testing using minimal patient‐derived tumor material. By screening nanoliter‐scale droplets containing as few as 300 cells, this approach generates reproducible and tumor‐specific drug response profiles ...
Maryam Salarian   +7 more
wiley   +1 more source

Spider silk inspired strong yet tough composite hydrogels

open access: yes
Nanofillers are frequently used to improve the mechanical properties of hydrogels, but it is still difficult to develop composite hydrogels with simultaneously enhanced strength, fracture strain, toughness and fatigue threshold at a high water content ...
Tang, Longcheng   +11 more
core   +1 more source

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