Results 51 to 60 of about 1,083,921 (267)

Status quo, challenges and future directions of hydrogen medicine

Fundamental Research
The hydrogen molecule (H2) has distinctive characteristics and advantages in broad-spectrum anti-inflammation, high biosafety and strong tissue permeability, exhibiting a therapeutic potential in numerous diseases associated with inflammation and ...
Shengqiang Chen, Lingting Zeng, Qianjun He   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Deactivation mechanism for water splitting: Recent advances

Carbon Energy
Hydrogen (H2) has been regarded as a promising alternative to fossil‐fuel energy. Green H2 produced via water electrolysis (WE) powered by renewable energy could achieve a zero‐carbon footprint.
Yansong Jia, Yang Li, Qiong Zhang, Sohail Yasin, Xinyu Zheng, Kai Ma, Zhengli Hua, Jianfeng Shi, Chaohua Gu, Yuhai Dou, Shixue Dou   +10 more
doaj   +1 more source

Thermogravimetric Analysis of Char Waste from the Air Gasification of Empty Fruit Bunch Briquette.

MATEC Web of Conferences, 2014
The thermal decomposition behavior of char waste produced from the air gasification of Empty Fruit Bunch (EFB) briquette was examined using thermogravimetric analysis (TGA).
Nyakuma Bemgba Bevan, Mazangi Mojtaba, Johari Anwar, Ahmad Arshad, Tuan Abdullah Tuan Amran   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Regulating Water Transport Paths on Porous Transport Layer by Hydrophilic Patterning for Highly Efficient Unitized Regenerative Fuel Cells

Nano-Micro Letters
Highlights Novel amphiphilic patterned titanium porous transport layers (PTLs) significantly enhance the round-trip efficiency of unitized regenerative fuel cells (URFCs), achieving an impressive round-trip efficiency of 25.7% at a current density of 2 A
Sung Min Lee, Keun Hwan Oh, Hwan Yeop Jeong, Duk Man Yu, Tae-Ho Kim   +4 more
doaj   +1 more source

Effect of pore morphology and surface roughness on wettability of porous titania films

Materials Research Express, 2020
Surface hydrophobicity/hydrophilicity of titania (TiO _2 ) films, spin-coated on silicon wafers, were tuned by introducing surface mesopores with various morphologies using a triblock copolymer F38 as the template agent of different weight ratios via a ...
Bangyun Xiong, Jingjing Li, Chunqing He, Xiuqin Tang, Zizhao Lv, Xiaofeng Li, Xiqiang Yan   +6 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source