Results 51 to 60 of about 1,126,577 (268)

Highly thermally conductive composite films by the rational assembly of aramid nanofibers with low-dimensional nanofillers

Journal of Materials Research and Technology
Highly efficient thermal management of electronic devices has grown in significance with the burgeoning of semiconductor technology and 5th generation communication.
Xuyun Liang, Gaofa Chen, Qingshan Wu, Haichen Zhang, Rongjian Zhong, Xianghong Zeng, Dechao Hu, Jing Lin   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Status quo, challenges and future directions of hydrogen medicine

Fundamental Research
The hydrogen molecule (H2) has distinctive characteristics and advantages in broad-spectrum anti-inflammation, high biosafety and strong tissue permeability, exhibiting a therapeutic potential in numerous diseases associated with inflammation and ...
Shengqiang Chen, Lingting Zeng, Qianjun He   +2 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Deactivation mechanism for water splitting: Recent advances

Carbon Energy
Hydrogen (H2) has been regarded as a promising alternative to fossil‐fuel energy. Green H2 produced via water electrolysis (WE) powered by renewable energy could achieve a zero‐carbon footprint.
Yansong Jia, Yang Li, Qiong Zhang, Sohail Yasin, Xinyu Zheng, Kai Ma, Zhengli Hua, Jianfeng Shi, Chaohua Gu, Yuhai Dou, Shixue Dou   +10 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Thermogravimetric Analysis of Char Waste from the Air Gasification of Empty Fruit Bunch Briquette.

MATEC Web of Conferences, 2014
The thermal decomposition behavior of char waste produced from the air gasification of Empty Fruit Bunch (EFB) briquette was examined using thermogravimetric analysis (TGA).
Nyakuma Bemgba Bevan, Mazangi Mojtaba, Johari Anwar, Ahmad Arshad, Tuan Abdullah Tuan Amran   +4 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Regulating Water Transport Paths on Porous Transport Layer by Hydrophilic Patterning for Highly Efficient Unitized Regenerative Fuel Cells

Nano-Micro Letters
Highlights Novel amphiphilic patterned titanium porous transport layers (PTLs) significantly enhance the round-trip efficiency of unitized regenerative fuel cells (URFCs), achieving an impressive round-trip efficiency of 25.7% at a current density of 2 A
Sung Min Lee, Keun Hwan Oh, Hwan Yeop Jeong, Duk Man Yu, Tae-Ho Kim   +4 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source