Results 61 to 70 of about 1,745,776 (318)

Heavy hydrogen in the stratosphere [PDF]

, 2003
We report measurements of the deuterium content of molecular hydrogen (H2) obtained from a suite of air samples that were collected during a stratospheric balloon flight between 12 and 33 km at 40º N in October 2002. Strong deuterium enrichments of up to
Rhee, T.S., Rhee, T., Engel, A., Röckmann, Thomas, A. Engel, Rhee, T. S., Rhee, Tae Siek, T. Röckmann, T. S. Rhee, Engel, Andreas, Röckmann, T.   +10 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

SUSTAINABILITY ANALYSIS OF HYDROGEN PRODUCTION PROCESSES

, 2022
Hydrogen is a versatile energy carrier and storage medium that may be employed in a variety of applications. It may be produced using different processes, each one generating a peculiar hydrogen identified by a color.
Fermeglia M., Mio A., Barbera E., Pavan A. M., Bertucco A.   +4 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Cutting-edge advances in hydrogen applications for the medical and pharmaceutical industries [PDF]

This article is part of a special issue entitled: ICEESEN-2024 (Akansu) published in International Journal of Hydrogen Energy.The adoption of clean hydrogen is expected to transform the global energy landscape, reducing greenhouse gas emissions, bridging
Alhajeri, A, Ghazal, H, Kodresko, A, Jouhara, H, Olabi, V   +4 more
core   +1 more source

Hydrogen transport and embrittlement in 300 M and AerMet100 ultra high strength steels [PDF]

, 2010
This paper describes how hydrogen transport affects the severity of hydrogen embrittlement in 300 M and AerMet100 ultra high strength steels. Slow strain rate tests were carried out on specimens coated with electrodeposited cadmium and aluminium-based
Robinson, M. J., Figueroa-Gordon, Douglas J.   +1 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Highly thermally conductive composite films by the rational assembly of aramid nanofibers with low-dimensional nanofillers

Journal of Materials Research and Technology
Highly efficient thermal management of electronic devices has grown in significance with the burgeoning of semiconductor technology and 5th generation communication.
Xuyun Liang, Gaofa Chen, Qingshan Wu, Haichen Zhang, Rongjian Zhong, Xianghong Zeng, Dechao Hu, Jing Lin   +7 more
doaj   +1 more source

Artificial intelligence and robotics in the hydrogen lifecycle: A systematic review [PDF]

Data availability statement: No data has been generated in this work.Hydrogen lifecycle, encompassing production, storage, and transportation, is crucial in the global transition to clean energy.
Duan, L, Huda, MN, Quintanilla, P, Lai, CS, Masoudi Soltani, S, Elhalwagy, A, Foroudi, P, Nandy, M   +7 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source