Results 51 to 60 of about 816,336 (269)

Ti6Al4V-0.72H on the Establishment of Flow Behavior and the Analysis of Hot Processing Maps

Crystals
Significant columnar grains usually occur in the metallurgical microstructure of laser additive manufacturing, and plastic deformation introduced into additive manufacturing can significantly refine grain size.
Jian-Hua Sun, Hai Gu, Jie Zhang, Jie Jiang, Guo-Qing Wu, Zhong-Gang Sun   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

HYDROGEN ADDITION ON COMBUSTION AND EMISSION CHARACTERISTICS OF HIGH SPEED SPARK IGNITION ENGINE- AN EXPERIMENTAL STUDY [PDF]

Journal of Engineering Science and Technology, 2016
The present article aims at characterizing the combustion and emission parameters of a single cylinder high speed SI engine operating with different concentrations of hydrogen with gasoline fuel.
SHIVAPRASAD K. V. , P. R. CHITRAGAR, KUMAR G. N.   +2 more
doaj  

Experimental Study on Zn-Doped Al-Rich Alloys for Fast on-Board Hydrogen Production

Crystals, 2020
For the purpose of investigating the effect of Zn replacement of In3Sn on the hydrogen production performance of Al-rich alloy ingots, Al-Ga-In3Sn alloys with various Zn dosages (0−5 wt.%) were prepared by a traditional melting and casting ...
Dan Liu, Qian Gao, Qi An, Hongchao Wang, Jilun Wei, Cundi Wei   +5 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Influences of hydrogen addition from different dual‐fuel modes on engine behaviors

Energy Science & Engineering, 2022
Compression ignition (CI) engines have good performance but more exhaust emissions. Dual fuel (DF) engines have better performance and lower emissions compared to CI mode.
Sanjeevakumar Veerasangappa Khandal, Ümit Ağbulut, Asif Afzal, Mohsen Sharifpur, Kaladgi Abdul Razak, Nima Khalilpoor   +5 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Enhancing Diesel Engine Performance Through Hydrogen Addition

Fire
This study evaluates the potential of hydrogen as a clean additive to conventional diesel fuel. Experiments were carried out on a single-cylinder, air-cooled diesel engine under half- and full-load conditions, across engine speeds ranging from 1000 to ...
Sahbi Ben Abdelwahed, Fakher Hamdi, Mehrez Gassoumi, Ilham Yahya, Noomen Moussa, Nashmi H. Alrasheedi, Ridha Ennetta, Borhen Louhichi   +7 more
doaj   +1 more source