Results 91 to 100 of about 1,936,115 (314)
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Low-concentrated nonvital bleaching effect on bond strength of composite resin restorations
Brazilian Dental Science, 2016 Objective: To investigate if short-term dentin bleaching with low-concentrated substances affects the bond strength of immediate resin composite restorations.
Fabiana Gomes Néspoli +5 more
doaj +1 more source
Hydrogen-Bond-Assisted Symmetry Breaking in a Network of Chiral Metal-Organic Assemblies. [PDF]
, 2019 Herein we elucidate the interplay of chiral, chelate, solvent, and hydrogen-bonding information in the self-assembly of a series of new three-dimensional metal-organic architectures.
Patrick Pröhm (6239552) +4 more
core +2 more sources
Effect of terahertz irradiation on DNA damage repair in living cells
FEBS Open Bio, EarlyView.We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno +3 more
wiley +1 more source
Fast Collective Hydrogen-Bond Dynamics in Hexafluoroisopropanol Related to its Chemical Activity [PDF]
Using fluorinated mono-alcohols, in particular hexafluoro-2-propanol (HFIP), as a solvent can enhance chemical reaction rates in a spectacular manner.
Johannes , Hunger +4 more
core +2 more sources
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
, 2023 The field of anticancer nanomedicine seeks to boost the arsenal’s exploitation with intelligent performance. One opportunistic choice comes from the fabrication of amphiphilic polymer micelles that are reversibly crosslinked. Here, hydrogen-bond (H-bond)-
Yanggui Wu (13803548) +5 more
core +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
The hydrogen bond H-bond analysis.
, 2022 (A) H-bond average values of seven investigated compounds. (B) Hydrogen bond occupancy of 7 ligands by residues in 50 ns simulations trajectories, only interactions with a frequency greater than 30% were presented.
Que-Huong Tran (12133378) +5 more
core +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source