Results 71 to 80 of about 1,936,115 (314)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Journal of Molecular Structure: THEOCHEM, 1994 There seems to be increasing interest in the electron density distribution in molecules and crystals. In particular, the effect of polarization due to internal fields in condensed matter is studied. X-ray diffraction data can contribute to the knowledge required.
Poorthuis, G.H.A., Feil, D.
openaire +1 more source
(2E)-2-(3-Ethoxy-2-hydroxybenzylidene)hydrazinecarboxamide
Acta Crystallographica Section E, 2013 The title compound, C10H13N3O3, adopts an E conformation with respect to the azomethine bond and crystallizes in the amide form. A classical intramolecular O—H...N hydrogen bond is present.
A. Ambili Aravindakshan +2 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Crystals, 2020 The aim of this work was to synthesize zeolitic imidazolate framework-8 (ZIF-8) by an alternative method and then modify the surface properties for enhancing the CO2 adsorption performance.
Kasama Kenyotha +3 more
doaj +1 more source
Hydrogen bonding in organic systems: a study using x-ray and neutron diffraction and database analyses. [PDF]
, 1999 This thesis covers three topics related to the field of crystal engineering. Three different approaches to improving the understanding of hydrogen bonding are covered; analysis of a family of related molecules, investigations of specific functional ...
Bilton, Clair
core
, 2020 We have employed the QM(CASPT2//CASSCF)/MM method to explore the excited-state isomerization and decay mechanism of a single-bond-rotation locked photoactive yellow protein (PYP) chromophore in wild-type and mutant proteins.
Ganglong Cui (1329708) +4 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2015 The title compound contains a symmetric hydrogen bond in which the H atom does not lie on a crystallographic centre of symmetry. The structure of K2[H7CrIIIMo6O24]·8H2O, namely dipotassium heptahydrogen hexamolybdochromate(III) octahydrate, previously ...
Hea-Chung Joo, Ki-Min Park, Uk Lee
doaj +1 more source
, 2017 In the present work, the cooperativity between hydrogen bond‒hydrogen bond, halogen bond‒halogen bond and hydrogen bond‒halogen bond in ternary FX…diazine…XF (X = H and Cl) complexes is theoretically investigated.
Mahdiyeh Ranjbar (3210702) +2 more
core +1 more source