Results 41 to 50 of about 2,615,661 (354)
The Characteristics of PD-L1 Inhibitors, from Peptides to Small Molecules
Molecules, 2019 The programmed cell death ligand protein 1 (PD-L1) is a member of the B7 protein family and consists of 290 amino acid residues. The blockade of the PD-1/PD-L1 immune checkpoint pathway is effective in tumor treatment.
Yanwen Zhong +3 more
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
2-[(Pyridin-3-ylamino)methyl]phenol
Acta Crystallographica Section E, 2011 In the title compound, C12H12N2O, the aromatic rings at either ends of the –CH2–NH– link are twisted by 68.79 (7)°.
Jing Xu, Shan Gao, Seik Weng Ng
doaj +1 more source
How Strong Is the Hydrogen Bond in Hybrid Perovskites?
Journal of Physical Chemistry Letters, 2017 Hybrid organic–inorganic perovskites represent a special class of metal–organic framework where a molecular cation is encased in an anionic cage. The molecule–cage interaction influences phase stability, phase transformations, and the molecular dynamics.
K. Svane +6 more
semanticscholar +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Quantifying hydrogen bonding using electrically tunable nanoconfined water
Nature CommunicationsHydrogen bonding plays a crucial role in biology and technology, yet it remains poorly understood and quantified despite its fundamental importance. Traditional models, which describe hydrogen bonds as electrostatic interactions between electropositive ...
Ziwei Wang +13 more
doaj +1 more source
l-Alanine hydrochloride monohydrate
Acta Crystallographica Section E, 2008 Colorless crystals of l-alanine hydrochloride monohydrate, C3H8NO2+·Cl−·H2O, were obtained from a powder sample that had been left standing in a refrigerator for a few years.
Shigeyuki Yokoyama +4 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Quantum delocalization of protons in the hydrogen-bond network of an enzyme active site [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2014 Significance Because of the low mass of the proton, nuclear quantum effects can dramatically alter the properties of hydrogen-bond networks, especially when short and strong hydrogen bonds occur.
Lu Wang, S. Fried, S. Boxer, T. Markland
semanticscholar +1 more source