Results 81 to 90 of about 323,304 (307)
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Hydrogen Bonding in Amorphous Indomethacin
PharmaceuticsAmorphous Indomethacin has enhanced bioavailability over its crystalline forms, yet amorphous forms can still possess a wide variety of structures. Here, Empirical Potential Structure Refinement (EPSR) has been used to provide accurate molecular models ...
C. J. Benmore +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
, 2019 We report herein a strategy of ammonium hydrogen-bonding-assisted α-F elimination from Cu–CF3 compounds that generates R3N·HF reagents in situ. Combining this strategy and Cu(III)–CF3 chemistry with alkynes, dual fluorination and trifluoromethylation of
Song-Lin Zhang (1446973) +1 more
core +1 more source
, 2023 Epoxide-functionalization has emerged as an effective strategy for enhancing the oxidative stability of poly(ethylenimine)-based CO2 capture sorbents. However, the underlying mechanism remains largely unexplored. Here we combine first-principles modeling,
Marcos F. C., Andrade +7 more
core +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Stimuli-responsive light-emitting polymers (SRLEPs) have many promising applications. However, the synthesis of SRLEPs from nonconjugated and water-soluble monomers remains a challenge.
Shunfeng Yu (13890082) +8 more
core +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Hydrogen-Bonding Interactions in T-2 Toxin Studied Using Solution and Solid-State NMR
Toxins, 2011 The structure of T-2 toxin in the solid-state is limited to X-ray crystallographic studies, which lack sufficient resolution to provide direct evidence for hydrogen-bonding interactions.
Paul Hazendonk +6 more
doaj +1 more source