Results 61 to 70 of about 323,304 (307)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
2,4,5-Trimethoxybenzaldehyde monohydrate
Acta Crystallographica Section E, 2010 In the title compound, C10H12O4·H2O, the 2,4,5-trimethoxybenzaldehyde molecule is almost planar (rms deviation = 0.0183 Å). There is an R12(5) ring motif due to O—H...O hydrogen bonding. In the crystal, the molecules
Abdullah M. Asiri +2 more
doaj +1 more source
Interplay between Position-Dependent Codon Usage Bias and Hydrogen Bonding at the 5ʹ End of ORFeomes
mSystems, 2020 Codon usage bias exerts control over a wide variety of molecular processes. The positioning of synonymous codons within coding sequences (CDSs) dictates protein expression by mechanisms such as local translation efficiency, mRNA Gibbs free energy, and ...
Juan C. Villada +2 more
doaj +1 more source
Research, 2023 Hydrogen bonds are non-covalent interactions and essential for assembling supermolecules into ordered structures in biological systems, endowing crystals with fascinating physical properties, and inspiring the construction of eco-friendly ...
Hui Yuan +7 more
doaj +1 more source
Materials Integrations for High-Performance Photovoltaics by Wafer Bonding [PDF]
, 2005 The fundamental efficiency limit for state of the art triple-junction photovoltaic devices is being approached. By allowing integration of non-lattice-matched materials in monolithic structures, wafer bonding enables novel photovoltaic devices that have ...
Zahler, James Michael
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Crystals, 2019 Amino acid complexes of transition metals show interesting hydrogen-bonding motifs. In this paper, the syntheses and structures of three β-amino acid complexes of palladium that differ only by the substitution on the β-carbon will be discussed.
David B. Hobart +4 more
doaj +1 more source
SOLITONS IN HYDROGEN-BONDED CHAINS
Le Journal de Physique Colloques, 1988 A one dimensional model for hydrogen bonded chains is investigated by including the dynamical degrees of freedom of the oxygens and thus generalizing the original Antonchenko-Davydov-Zolotaryuk model. Analytical solutions are derived within a continuum approximation up to second order so that rather narrow solutions could be derived accurately enough ...
Desfontaines, H. +3 more
openaire +2 more sources
Development of building blocks exhibiting self-sorting molecular recognition properties: towards coded self-assembly processes [PDF]
, 2012 Biology can achieve phenomenal information storage/processing capabilities from just four hydrogen bonding molecules. The orthogonal self-sorting of these four hydrogen bonding motifs is achieved alongside the hydrophobic collapse of the DNA backbone ...
Pellizzaro, Maria Louise
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source