Results 41 to 50 of about 2,002,951 (308)
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
FEBS Letters, EarlyView.Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia +5 more
wiley +1 more source
Occurrence of Chiral Nanostructures Induced by Multiple Hydrogen Bonds.
Journal of the American Chemical Society, 2019 Developing artificial systems to mimic the emergence of chirality is of vital importance in better understanding the mysterious origin of natural homochirality and guiding the design of advanced chiroptical materials.
Pengyao Xing +6 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii +8 more
wiley +1 more source
Hydrogen Bonds and Life in the Universe
Life, 2018 The scientific community is allocating more and more resources to space missions and astronomical observations dedicated to the search for life beyond Earth.
G. Vladilo, A. Hassanali
semanticscholar +1 more source
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
2-(Ethylsulfinyl)imidazo[1,2-a]pyridine-3-sulfonamide
Acta Crystallographica Section E, 2012 The supramolecular structure of the title compound, C9H11N3O3S2, is defined by two intermolecular hydrogen bonds. Pairs of N—H...N hydrogen bonds link the molecules into centrosymmetric dimers and N—H...O hydrogen bonds link the ...
Jing Li, Haixia Ma, Yaling Gong
doaj +1 more source
FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
2,6-Diamino-4-chloropyrimidinium 4-carboxybutanoate
Acta Crystallographica Section E, 2014 In the title molecular salt, C4H6ClN4+·C5H7O4−, the cation is essentially planar, with a maximum deviation of 0.037 (1) Å for all non-H atoms. The anions are self-assembled through O—H...O hydrogen bonds, forming a supramolecular zigzag chain with graph ...
Bellarmin Edison +5 more
doaj +1 more source
NMR and IR Investigations of Strong Intramolecular Hydrogen Bonds
Molecules, 2017 For the purpose of this review, strong hydrogen bonds have been defined on the basis of experimental data, such as OH stretching wavenumbers, νOH, and OH chemical shifts, δOH (in the latter case, after correction for ring current effects). Limits for O–H·
P. Hansen, J. Spanget-Larsen
semanticscholar +1 more source