Results 41 to 50 of about 378,429 (252)

Melaminium iodide monohydrate

Acta Crystallographica Section E, 2010
In the title melaminium salt, 2,4,6-triamino-1,3,5-triazin-1-ium iodide monohydrate, C3H7N6+·I−·H2O, the components are linked via N—H...O, N—H...N, O—H...I and N—H...I hydrogen bonds ...
Min Min Zhao, Ping Ping Shi
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Pyridine-4-carboximidamidate chloride

Acta Crystallographica Section E, 2009
In the title salt, C6H8N3+·Cl−, each pyridinecarboximidamidate cation is linked to two symmetry-related cations through N—H...N hydrogen bonds, and to two chloride ions by N—H...Cl hydrogen bonds. The N—H..
Ping Fan, Lei Wang, Huidong Zhang
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

1,5-Bis[1-(2,4-dihydroxyphenyl)ethylidene]carbonohydrazide dimethylformamide disolvate

Acta Crystallographica Section E, 2010
In the title compound, C17H18N4O5·2C3H7NO, two solvent molecules are linked to the main molecule via N—H...O and O—H...O hydrogen bonds, forming a hydrogen-bonded trimer.
Qing-Peng He, Bo Tan, Ze-Hua Lu
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

1H-Benzo[d]imidazol-3-ium (Z)-3-carboxyprop-2-enoate

IUCrData, 2016
In the anion of the title molecular salt, C7H7N2+.C4H3O4−, an O—H...O hydrogen bond generates an S(7) graph-set motif while a pair of intermolecular N—H...O and C—H...O hydrogen bonds generate an R44(10) ring-motif.
M. Amudha, B. Gunasekaran, P. Praveen Kumar, G. Chakkaravarthi   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Hydrogen bonding [PDF]

Current Biology, 1999
K.M Harmon, A.C Webb
openaire   +3 more sources

5-Amino-1H-1,2,4-triazol-4-ium hydrogen oxalate

Acta Crystallographica Section E, 2013
In the title salt, C2H5N4+·C2HO4−, the hydrogen oxalate anions form corrugated chains parallel to the c axis, linked by intermolecular O—H...O hydrogen bonds.
Mohamed Rzaigui, Salem S. Al-Deyab, Houda Marouani, Manel Essid   +3 more
doaj   +1 more source