Results 61 to 70 of about 2,348,481 (310)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Pyridine-4-carboximidamidate chloride
Acta Crystallographica Section E, 2009 In the title salt, C6H8N3+·Cl−, each pyridinecarboximidamidate cation is linked to two symmetry-related cations through N—H...N hydrogen bonds, and to two chloride ions by N—H...Cl hydrogen bonds. The N—H..
Ping Fan, Lei Wang, Huidong Zhang
doaj +1 more source
Hydrogen Bonds and Life in the Universe
Life, 2018 The scientific community is allocating more and more resources to space missions and astronomical observations dedicated to the search for life beyond Earth.
G. Vladilo, A. Hassanali
semanticscholar +1 more source
SOLITONS IN HYDROGEN-BONDED CHAINS
Le Journal de Physique Colloques, 1988 A one dimensional model for hydrogen bonded chains is investigated by including the dynamical degrees of freedom of the oxygens and thus generalizing the original Antonchenko-Davydov-Zolotaryuk model. Analytical solutions are derived within a continuum approximation up to second order so that rather narrow solutions could be derived accurately enough ...
Desfontaines, H. +3 more
openaire +2 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
1,5-Bis[1-(2,4-dihydroxyphenyl)ethylidene]carbonohydrazide dimethylformamide disolvate
Acta Crystallographica Section E, 2010 In the title compound, C17H18N4O5·2C3H7NO, two solvent molecules are linked to the main molecule via N—H...O and O—H...O hydrogen bonds, forming a hydrogen-bonded trimer.
Qing-Peng He, Bo Tan, Ze-Hua Lu
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
N,N-Dibutylanilinium hydrogen squarate
IUCrData, 2017 The title molecular salt, C14H24N+·C4HO4− [systematic name: N,N-dibutylbenzenaminium 2-hydroxy-3,4-dioxocyclobut-1-en-1-olate], is composed of a protonated N,N-dibutylaniline cation with a hydrogen squarate monoanion (common names).
Daron E. Janzen +2 more
doaj +1 more source
NMR and IR Investigations of Strong Intramolecular Hydrogen Bonds
Molecules, 2017 For the purpose of this review, strong hydrogen bonds have been defined on the basis of experimental data, such as OH stretching wavenumbers, νOH, and OH chemical shifts, δOH (in the latter case, after correction for ring current effects). Limits for O–H·
P. Hansen, J. Spanget-Larsen
semanticscholar +1 more source