Results 41 to 50 of about 410,476 (216)
Pyridine-4-carboximidamidate chloride
Acta Crystallographica Section E, 2009 In the title salt, C6H8N3+·Cl−, each pyridinecarboximidamidate cation is linked to two symmetry-related cations through N—H...N hydrogen bonds, and to two chloride ions by N—H...Cl hydrogen bonds. The N—H..
Ping Fan, Lei Wang, Huidong Zhang
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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1,5-Bis[1-(2,4-dihydroxyphenyl)ethylidene]carbonohydrazide dimethylformamide disolvate
Acta Crystallographica Section E, 2010 In the title compound, C17H18N4O5·2C3H7NO, two solvent molecules are linked to the main molecule via N—H...O and O—H...O hydrogen bonds, forming a hydrogen-bonded trimer.
Qing-Peng He, Bo Tan, Ze-Hua Lu
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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N,N-Dibutylanilinium hydrogen squarate
IUCrData, 2017 The title molecular salt, C14H24N+·C4HO4− [systematic name: N,N-dibutylbenzenaminium 2-hydroxy-3,4-dioxocyclobut-1-en-1-olate], is composed of a protonated N,N-dibutylaniline cation with a hydrogen squarate monoanion (common names).
Daron E. Janzen +2 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
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Bis(2-amino-5-methylpyridinium) fumarate–fumaric acid (1/1)
Acta Crystallographica Section E, 2010 In the crystal structure of the title compound, C6H9N2+·0.5C4H2O42−·0.5C4H6O4, the fumarate dianion and fumaric acid molecule are located on inversion centres.
Madhukar Hemamalini, Hoong-Kun Fun
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Vodikove veze s metalima (Hydrogen Bonds Involving Metal Centers) [PDF]
Kemija u Industriji, 2006 Hydrogen bonds involving metal center as a hydrogen donor or hydrogen acceptor are only a specific type of metal-hydrogen interactions; it is therefore not easy to differentiate hydrogen bond from other metal-hydrogen interactions, especially agostic ...
Pavlović, G., Raos, N.
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1H-Benzo[d]imidazol-3-ium (Z)-3-carboxyprop-2-enoate
IUCrData, 2016 In the anion of the title molecular salt, C7H7N2+.C4H3O4−, an O—H...O hydrogen bond generates an S(7) graph-set motif while a pair of intermolecular N—H...O and C—H...O hydrogen bonds generate an R44(10) ring-motif.
M. Amudha +3 more
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