Results 71 to 80 of about 2,348,481 (310)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Bis(2-amino-5-methylpyridinium) fumarate–fumaric acid (1/1)

Acta Crystallographica Section E, 2010
In the crystal structure of the title compound, C6H9N2+·0.5C4H2O42−·0.5C4H6O4, the fumarate dianion and fumaric acid molecule are located on inversion centres.
Madhukar Hemamalini, Hoong-Kun Fun
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Vodikove veze s metalima (Hydrogen Bonds Involving Metal Centers) [PDF]

Kemija u Industriji, 2006
Hydrogen bonds involving metal center as a hydrogen donor or hydrogen acceptor are only a specific type of metal-hydrogen interactions; it is therefore not easy to differentiate hydrogen bond from other metal-hydrogen interactions, especially agostic ...
Pavlović, G., Raos, N.
doaj  

tert-Butyl N-{3-[(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino]propyl}carbamate

Acta Crystallographica Section E, 2012
In the title compound, C18H21ClN2O4, the molecular sytructure is stabilized by two intramolecular N—H...O hydrogen bonds. In the crystal, molecules are linked by pairs of C—H...O hydrogen bonds, forming inversion dimers with graph-set
Jackson A. L. C. Resende, Javier A. Gomez   +1 more
doaj   +1 more source

Hydrogen bonds to Au atoms in coordinated gold clusters

Nature Communications, 2017
It is well known that various transition elements can form M···H hydrogen bonds. However, for gold, there has been limited decisive experimental evidence of such attractive interactions.
M. Bakar, Mizuho Sugiuchi, M. Iwasaki, Yukatsu Shichibu, K. Konishi   +4 more
semanticscholar   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

1H-Benzo[d]imidazol-3-ium (Z)-3-carboxyprop-2-enoate

IUCrData, 2016
In the anion of the title molecular salt, C7H7N2+.C4H3O4−, an O—H...O hydrogen bond generates an S(7) graph-set motif while a pair of intermolecular N—H...O and C—H...O hydrogen bonds generate an R44(10) ring-motif.
M. Amudha, B. Gunasekaran, P. Praveen Kumar, G. Chakkaravarthi   +3 more
doaj   +1 more source

Interfacial Hydrogen Bonds and Their Influence Mechanism on Increasing the Thermal Stability of Nano-SiO2-Modified Meta-Aramid Fibres

Polymers, 2017
For further analysis of the effect of nano-doping on the properties of high polymers and research into the mechanism behind modified interfacial hydrogen bonds, a study on the formation probability of nano-SiO2/meta-aramid fibre interfacial hydrogen ...
Chao Tang, Xu Li, Zhiwei Li, J. Hao
semanticscholar   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source