Results 81 to 90 of about 197,550 (311)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Enhanced ammonia decomposition using a Pd-Ag membrane reactor for high-purity hydrogen production

open access: yesFuel Processing Technology
In this study, a Pd-Ag membrane reactor (MR) integrated with a lab-synthesized ruthenium catalyst supported on La2Ce2O7 was used for the efficient production and recovery of highly-pure hydrogen from ammonia decomposition.
Erasmo Salvatore Napolitano   +5 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Arenas of Expectations for Hydrogen Technologies [PDF]

open access: yes
Technological options can be regarded as variations in an evolutionary development process. The variations are put forward by their respective technological communities and are selected by technology selectors.
Harro van Lente   +2 more
core  

Silicon as an intermediary between renewable energy and hydrogen [PDF]

open access: yes, 2004
Weltweit nehmen Kohle-, Öl- und Erdgasvorräte ab, der Energiebedarf dagegen steigt dramatisch an. Regenerative Energien mindern zwar die steigenden Klimagefahren, können aber unseren zukünftigen Energiebedarf in Ballungszentren kaum decken.
Auner, Norbert
core  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Investigation of Diffusible Hydrogen Concentration in Gas Metal Arc Brazing by Carrier Gas Hot Extraction Method Referring to ISO 3690 [PDF]

open access: yes
110Arc brazing is an alternative joining technology well-suited for processing thermally sensitive materials and to produce mixed material connections.
Brätz, Oliver   +3 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Building and interconnecting hydrogen networks : insights from the electricity and gas experience in Europe [PDF]

open access: yes
This paper aims to investigate the transition to a new energy system based on hydrogen in the European liberalized framework. After analyzing the literature on the hydrogen infrastructure needs in Europe, we estimate the size and scope of the transition ...
Nuno Bento
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

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